73387-46-9

Basic information

• Product Name: 3-(4-BROMOPHENYL)-1H-PYRAZOLE, 97%
• Synonyms: 3-(4-Bromophenyl)-1H-pyrazole;1-Bromo-4-(1H-pyrazol-3-yl)benzene;3-(4-BroMophenyl)-1H-pyrazol;3-(4-bromophenyl)-2H-pyrazole;676292_ALDRICH;ZINC04293887
• CAS NO: 73387-46-9
• Molecular Formula: C₉H₇BrN₂
• Molecular Weight: 223.07
• Product Categories: Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrazoles;PyrazolesHeterocyclic Building Blocks;Building Blocks;C9;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 73387-46-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 132-136 °C
• Boiling Point: 388.9 °C at 760 mmHg
• Flash Point: 189 °C
• Appearance: /
• Density: 1.565
• Vapor Pressure: 6.66E-06mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.80±0.10(Predicted)
• CAS DataBase Reference: 3-(4-BROMOPHENYL)-1H-PYRAZOLE, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BROMOPHENYL)-1H-PYRAZOLE, 97%(73387-46-9)
• EPA Substance Registry System: 3-(4-BROMOPHENYL)-1H-PYRAZOLE, 97%(73387-46-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 73387-46-9(Hazardous Substances Data)

Usage

General Description

3-(4-Bromophenyl)-1H-pyrazole, 97% is a chemical compound that typically comes with a 97% purity concentration. This substance falls under the category of pyrazole, which is one of the most important heterocycles in the field of medicinal chemistry. While specifics of its properties can vary based on its treatment and combinations, it is known to have the bromine atom attached to the phenyl group, making it more reactive towards nucleophilic substitutions. It is often used in the synthesis of various pharmaceuticals and other organic compounds. However, as with many chemicals, careful handling is required due to potential health risks and reactivity.

InChI:InChI=1/C9H7BrN2/c10-8-3-1-7(2-4-8)9-5-6-11-12-9/h1-6H,(H,11,12)

Upstream product

• 73387-60-7 (2E)-1-(4-bromophenyl)-3-(dimethylamino)prop-2-en-1-one 
• 49678-04-8 4-bromocinnamaldeyde 
• 99-90-1 para-bromoacetophenone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 4592-94-3 3-(4-bromophenyl)-3-oxopropanenitrile 
• 37614-58-7 3-(4-bromophenyl)prop-2-yn-1-ol 

Downstream Products

• 1124-14-7 1-bromo-4-cyclopropylbenzene 
• 10557-11-6 4,4'-Dicyclopropyl-biphenyl 
• 26979-28-2 p-Cyclopropylphenyldiphenylmethanol 
• 26979-30-6 1-(Chloro-diphenyl-methyl)-4-cyclopropyl-benzene 
• 474707-80-7 3-(4-bromophenyl)-1-trityl-1H-pyrazole 
• 1021918-96-6 3-(4-(trimethylstannyl)phenyl)-1H-pyrazole 
• 1251931-40-4 3-(4-bromophenyl)-1-(4-methoxybenzyl)-1H-pyrazole 
• 17978-26-6 3-(4-bromophenyl)-4-chloro-1H-pyrazole 
• 1257300-50-7 3-(4-bromophenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole 
• 1199805-44-1 3-(4-bromophenyl)-1-ethyl-1H-pyrazole 
• 1199805-45-2 tert-butyl (2E)-3-[4-(1-ethyl-1H-pyrazol-3-yl)phenyl]prop-2-enoate 
• 1394374-29-8 3-(4-bromophenyl)-1-cyclopropyl-pyrazole 
• 73387-52-7 5-(4-bromophenyl)-1-methyl-1H-pyrazole 
• 73387-51-6 3-(4-bromophenyl)-1-methyl-1H-pyrazole 

Relevant articles and documents

Preparation method of pyrazole derivative (by machine translation)

The preparation method comprises the following steps: mixing an alkyne propyl alcohol derivative, a halogen source, an acid and a solvent, heating and reacting, and reacting to Meyer - Schuster generate the pyrazole derivative. Compared with the prior art, the preparation method disclosed by the invention has 91% the advantages of maximum yield, simple operation, mild conditions, high conversion rate, few byproducts and the like, and provides a brand-new synthetic method for construction of pyrazole compounds. (by machine translation)

Chemoselective Reduction of α-Cyano Carbonyl Compounds: Application to the Preparation of Heterocycles

β-Aminoacrylates are reactive intermediates that are useful building blocks in synthesis. General methods for their preparation typically afford α and β disubstitution patterns or β only. Molecules with only α-substituents (β-hydrogen) are much less well-known. A chemoselective reductive tautomerization of α-cyanoacetates, using DIBAL-H, has been developed to access these valuable synthons. α,β-Unsaturated cyanoacetates and α-cyanoketones can, also, be selectively reduced via this methodology. A series of heterocycles were prepared using these β-enamino carbonyl compounds.

A simple and efficient synthesis of pyrazoles in water

A simple, highly efficient, and environmentally friendly method for the synthesis of substituted 1H-pyrazoles by one-pot condensation reaction of α,β-unsaturated carbonyl compounds with tosyl hydrazide in water was developed. The reaction system exhibited tolerance with various functional groups, Aromatic moiety with both electron-rich and electron-deficient substituents could give desired products in good to excellent yields.