73387-51-6

Basic information

• Product Name: 3-(4-Bromophenyl)-1-methyl-1H-pyrazole
• Synonyms: 3-(4-Bromophenyl)-1-methyl-1H-pyrazole;3-(4-Bromophenyl)-1-methyl-1H-pyrazole 95%;1-Bromo-4-(1-methyl-1H-pyrazol-3-yl)benzene;3-(4-Bromophenyl)-1-methyl-1H-pyrazole95%
• CAS NO: 73387-51-6
• Molecular Formula: C₁₀H₉BrN₂
• Molecular Weight: 237.09586
• Mol File: 73387-51-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 79.5 °C
• Boiling Point: 331.6 °C at 760 mmHg
• Flash Point: 154.4 °C
• Appearance: /
• Density: 1.44 g/cm³
• Vapor Pressure: 0.000297mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-Bromophenyl)-1-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Bromophenyl)-1-methyl-1H-pyrazole(73387-51-6)
• EPA Substance Registry System: 3-(4-Bromophenyl)-1-methyl-1H-pyrazole(73387-51-6)

Safety Data

• Hazardous Substances Data: 73387-51-6(Hazardous Substances Data)

Usage

General Description

3-(4-Bromophenyl)-1-methyl-1H-pyrazole is a chemical compound with the molecular formula C10H9BrN2. It is a pyrazole derivative, which is a class of compounds commonly used in the pharmaceutical industry. This specific compound contains a bromine atom and a phenyl group attached to a pyrazole ring, as well as a methyl group at the 1-position of the pyrazole ring. Pyrazole derivatives have been studied for their potential pharmaceutical properties, including anti-inflammatory, analgesic, and antipyretic effects. 3-(4-Bromophenyl)-1-methyl-1H-pyrazole may have similar properties and could be a subject of further research for potential therapeutic applications.

InChI:InChI=1/C10H9BrN2/c1-13-7-6-10(12-13)8-2-4-9(11)5-3-8/h2-7H,1H3

Upstream product

• 73387-46-9 3-(4-bromophenyl)-1H-pyrazole 
• 74-88-4 methyl iodide 
• 99-90-1 para-bromoacetophenone 
• 54287-94-4 3-(4'-bromophenyl)-1-methylpyrazole 
• 108-86-1 bromobenzene 
• 33994-13-7 3-bromo-1-(4-bromophenyl)propan-1-one 
• 64487-10-1 1-(4-bromobenzylidene)-2-methylhydrazine 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 1607838-15-2 1-methyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrazole 
• 1607837-28-4 8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-3-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one 

Relevant articles and documents

Cascade reaction to 1H-pyrazoles from hydrazones via sodium Ni-trite promoted dual C–C/C–N formation, annulation and aromatization with 1,2-dichloroethane

A novel route for tandem C–C/C–N formation, annulation and aromatization of hydrazones with 1,2-dichloroethane to synthesize 1H-pyrazoles has been developed. Furthermore, the 1,2-dichloroethane serves as alkylation reagent in good to excellent yields. This methodology features mild reaction conditions and good functional group tolerance, providing a direct approach for the preparation of 1H-pyrazoles.

1,2,3,4-TETRAHYDROISOQUINOLINE COMPOUNDS AND COMPOSITIONS AS SELECTIVE ESTROGEN RECEPTOR ANTAGONISTS AND DEGRADERS

The present invention relates to compounds of formula (I) in which n, R1, R2, R3, R4and R5 are as defined in the claims; capable of being both potent antagonists and degraders of estrogen receptors. Also described is a process for the preparation of compounds of the invention, and the invention further provides pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.