73397-27-0

Basic information

• Product Name: N-BOC-(2S,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID
• Synonyms: N-BOC-(2S,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID;(2S,3S)-3-(Boc-aMino)-2-hydroxy-5-Methylhexanoic acid, 97%;(2S,3S)-3-((tert-butoxycarbonyl)aMino)- 2-hydroxy-5-Methylhexanoic acid;(2S,3S)-2-hydroxy-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid;N-(Tert-Butoxy)Carbonyl (2S,3S)-3-Amino-2-hydroxy-5-methyl-hexanoic acid
• CAS NO: 73397-27-0
• Molecular Formula: C₁₂H₂₃NO₅
• Molecular Weight: 261.32
• Mol File: 73397-27-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-BOC-(2S,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-(2S,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID(73397-27-0)
• EPA Substance Registry System: N-BOC-(2S,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID(73397-27-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 73397-27-0(Hazardous Substances Data)

Usage

Chemical Properties

White crystals

Upstream product

• 73397-31-6 (2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoic acid methyl ester 
• 222640-10-0 (3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-5-methylhexanoic acid 
• 774142-73-3 (2S,3S)-3-Amino-2-hydroxy-5-methyl-hexanoic acid methyl ester 
• 3183-10-6 N-phthalimide-L-leucinyl chloride 
• 318464-20-9 (2R,3S)-3-amino-2-hydroxy-5-methylhexanoic acid 
• 81322-90-9 phthalyl-L-leucinal cyanohydrin 
• 81322-83-0 (S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-methyl-2-trimethylsilanyloxy-hexanenitrile 
• 64490-39-7 N-phthalyl-L-leucinal 
• 2419-38-7 N-phthaloyl-(S)-leucine 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 62023-30-7 DL-threo-3-amino-2-hydroxy-5-methylhexanoic acid 
• 73397-25-8 (2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 73397-20-3 (2S,3S)-3-Amino-2-hydroxy-5-methylhexanoic Acid 

Downstream Products

• 77119-89-2 (S)-2-[(S)-2-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid methyl ester 
• 73397-34-9 (2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester 
• 73465-22-2 (2R,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester 
• 81322-85-2 (S)-2-{(S)-2-[(S)-2-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester 
• 73397-20-3 (2S,3S)-3-Amino-2-hydroxy-5-methylhexanoic Acid 
• 81322-88-5 (S)-2-[(S)-2-((2S,3S)-3-Amino-2-hydroxy-5-methyl-hexanoylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid methyl ester; hydrochloride 
• 81322-87-4 (S)-2-{(S)-2-[(S)-2-((2S,3S)-3-Amino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester; hydrochloride 
• 318464-20-9 (2R,3S)-3-amino-2-hydroxy-5-methylhexanoic acid 
• 73397-25-8 (2S,3R)-3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoic Acid 
• 73397-26-9 (2R,3R)-3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoic Acid 
• 73465-23-3 (2R,3R)-(3-Amino-2-hydroxy-5-methylhexanoyl)-L-valyl-L-valyl-L-aspartic Acid 
• 67655-94-1 amastatin 

Relevant articles and documents

TAXANE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The invention discloses an oxazolidine intermediate for the synthesis of 14- beta -hydroxy-1,14-carbonate-baccatines bearing a 13-isoserine substituent, and a process for the preparation thereof.

Renin Inhibitors. Substitution of the Leucyl Residues of Leu-Leu-Val-Phe-OCH3 with 3-Amino-2-hydroxy-5-methylhexanoic Acid

The 2S,3S and 2R,3S diastereoisomers of the hydroxy amino acid 3-amino-2-hydroxy-5-methylhexanoic acid (AHMHA) were synthesized and substituted for the leucyl residues of Leu-Leu-Val-Phe-OCH3 to yield the following analogues: AHMHA-Leu-Val-Phe-OCH3, AHMHA