73397-20-3Relevant articles and documents
TAXANE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
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Page 4; 14-16, (2008/06/13)
The invention discloses an oxazolidine intermediate for the synthesis of 14- beta -hydroxy-1,14-carbonate-baccatines bearing a 13-isoserine substituent, and a process for the preparation thereof.
Synthesis of (2S,3R)-3-Amino-2-hydroxy-5-methylhexanoic Acid: Bridging Effect of KF
Solladie-Cavallo, A.,Khiar, N.
, p. 4750 - 4754 (2007/10/02)
Natural (2S,3R)-3-amino-2-hydroxy-5-methylhexanoic acid is synthesized in 53-55percent yield (referred to (-)-8-phenylmenthol used as chiral auxiliary) by condensation of 1-nitro-3-methylbutane on (-)-8-phenylmenthol glyoxylate hydrate using KF as a mild base.With a large excess of KF in THF it has been possible to increase the diastereoselectivity of the nitro aldol condensation (up to I/II/III/IV = 77/13/10/0).
Synthesis and structure-activity relationships of amastatin analogues, inhibitors of aminopeptidase A
Tobe,Morishima,Aoyagi,et al.
, p. 1865 - 1872 (2007/10/02)
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