87024-12-2

Basic information

• Product Name: (S)-1-(2'-benzyloxycarbonylamino-4'-methylpentanoyl)-3,5-dimethylpyrazole
• Synonyms: (S)-1-(2'-benzyloxycarbonylamino-4'-methylpentanoyl)-3,5-dimethylpyrazole
• CAS NO: 87024-12-2
• Molecular Weight: 343.426
• Mol File: 87024-12-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-1-(2'-benzyloxycarbonylamino-4'-methylpentanoyl)-3,5-dimethylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(2'-benzyloxycarbonylamino-4'-methylpentanoyl)-3,5-dimethylpyrazole(87024-12-2)
• EPA Substance Registry System: (S)-1-(2'-benzyloxycarbonylamino-4'-methylpentanoyl)-3,5-dimethylpyrazole(87024-12-2)

Safety Data

• Hazardous Substances Data: 87024-12-2(Hazardous Substances Data)

Upstream product

• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 2018-66-8 Z-Leu-OH 
• 58889-73-9 (S)-N-benzyloxycarbonyl-leucine ethyl ester 
• 4703-53-1 N-benzyloxycarbonyl-L-leucine hydrazide 
• 123-54-6 acetylacetone 

Downstream Products

• 19739-60-7 Cbz-leucylglycyl hydrazide 
• 2867-06-3 Benzyloxycarbonylleucyl-glycine ethyl ester 
• 103820-93-5 ethyl N-benzyloxycarbonyl-L-leucyl-L-tyrosinate 
• 5084-98-0 methyl N-benzyloxycarbonyl-L-leucylglicynate 
• 318464-20-9 (2R,3S)-3-amino-2-hydroxy-5-methylhexanoic acid 
• 73397-20-3 (2S,3S)-3-Amino-2-hydroxy-5-methylhexanoic Acid 

Relevant articles and documents

New system for peptide synthesis using N-acylpyrazoles

New system of peptide synthesis was described. The extension of one amino acid unit on the peptide chain was constituted from only 2 reaction steps, the conversion from esters to the corresponding N-acylpyrazoles and the subsequent aminolysis with amino esters. This new system was distinctive from the conventional peptide synthesis, which was consisted of 3 steps of the deprotection, the activation and the condensation. Moreover, the key intermediate N-acylpyrazoles exhibited the excellent properties of high sensitivity and separability for the chiral column on HPLC using the UV detector.

Synthesis and structure-activity relationships of amastatin analogues, inhibitors of aminopeptidase A

-