58889-73-9

Basic information

• Product Name: L-Leucine, N-[(phenylmethoxy)carbonyl]-, ethyl ester
• CAS NO: 58889-73-9
• Molecular Formula: C16H23NO4
• Molecular Weight: 293.363
• Mol File: 58889-73-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[(phenylmethoxy)carbonyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[(phenylmethoxy)carbonyl]-, ethyl ester(58889-73-9)
• EPA Substance Registry System: L-Leucine, N-[(phenylmethoxy)carbonyl]-, ethyl ester(58889-73-9)

Safety Data

• Hazardous Substances Data: 58889-73-9(Hazardous Substances Data)

Upstream product

• 2018-66-8 Z-Leu-OH 
• 64-17-5 ethanol 
• 621-84-1 O-benzyl carbamate 
• 44396-74-9 isobutylzinc iodide 
• 134746-23-9 ethyl 2-(((benzyloxy)carbonyl)amino)-2-chloroacetate 
• 227184-97-6 1-(4-isobutyl-5-oxo-4,5-dihydro-oxazol-2-yl)-3-methyl-butyl-carbamic acid benzyl ester 
• 7801-71-0 N-benzyloxycarbonyl-L-leucyl-L-leucine 
• 2743-40-0 L-leucine ethyl ester hydrochloride 
• 501-53-1 benzyl chloroformate 
• 541-41-3 chloroformic acid ethyl ester 
• 127825-05-2 diphenyl <1-amino-2-(4-methoxyphenyl)>ethylphosphonate 
• 2018-66-8 N-carbobenzyloxy leucine 

Downstream Products

• 60566-42-9 L-phenylalanyl-L-leucine ethyl ester 
• 3982-72-7 Cbz-Gly-L-Phe-L-Leu-OEt 
• 2953-42-6 Z-phenylalanylleucine ethyl ester 
• 132549-28-1 (E)-(S)-4-Benzyloxycarbonylamino-6-methyl-hept-2-enoic acid methyl ester 
• 111854-80-9 (Z)-(S)-4-Benzyloxycarbonylamino-6-methyl-hept-2-enoic acid methyl ester 
• 49642-07-1 statine 
• 86852-24-6 (S)-dimethyl 2-(2'-benzyloxycarbonylamino-4'-methylpentylidene)malonate 
• 87024-12-2 (S)-1-(2'-benzyloxycarbonylamino-4'-methylpentanoyl)-3,5-dimethylpyrazole 
• 19739-60-7 Cbz-leucylglycyl hydrazide 
• 2867-06-3 Benzyloxycarbonylleucyl-glycine ethyl ester 
• 4703-53-1 N-benzyloxycarbonyl-L-leucine hydrazide 
• 6216-61-1 (S)-(-)-N-(benzyloxycarbonyl)leucinol 
• 70853-26-8 N-carbobenzoxy-L-leucinal 

Relevant articles and documents

Asymmetric Synthesis of Protected Unnatural α-Amino Acids via Enantioconvergent Nickel-Catalyzed Cross-Coupling

Interest in unnatural α-Amino acids has increased rapidly in recent years in areas ranging from protein design to medicinal chemistry to materials science. Consequently, the development of efficient, versatile, and straightforward methods for their enanti

MIXED CARBOXYLIC - CARBONIC ANHYDRIDE METHOD IN PHOSPHONO PEPTIDE SYNTHESIS

Factors influencing the reaction yields and formation of the side products during coupling of N-carbobenzoxyamino acids with dialkyl or diphenyl aminoalkylphosphonates, by means of mixed anhydryde procedure, were evaluated.The recommended procedure, arising from these studies, involves the use of chloroform/ethyl chloroformate/triethylamine system and delicate warming of the reaction mixture during the coupling step.

UTILISATION DES HYDROLASES EN CHIMIE ORGANIQUE: SYNTHESE DE LIAISONS ESTER ET AMIDE CATALYSEE PAR LA PAPAINE INDUSTRIELLE

The use of hydrolases in organic chemistry: synthesis of amide and ester bonds catalyzed by industrial papain.Industrial papain, which is readily available, catalyzed the synthesis of L-Z-alanine ethyl ester (L-ZAEt) in organic medium, under different conditions, with good yields.L-ZAEt was obtained from DL-Z-alanine with 100 percent optical purity.We studied the effects of pH, the solvent/substrate and papain/substrate ratios and the type of organic solvent added, on the L-ZAEt yield.Unreactive D-ZA was also easily isolated from the aqueous phase with good optical purity.This attractive method has been applied to other N-Z-amino acid esters with the same succes.This procedure has been developed for the preparation of peptides using carboxylic or phosphonic substrates.These peptides have anti-bacterial activity. enzymatic catalysis / papain / chymopapain / stereospecific esterification of carboxylic amino acids / dipeptides / phosphonopeptides / anti-bacterial activity