7394-79-8

Basic information

• Product Name: 3-(5-methyl-1H-indol-3-yl)propanoic acid
• Synonyms: 3-(5-methyl-1H-indol-3-yl)propanoic acid
• CAS NO: 7394-79-8
• Molecular Weight: 203.241
• Mol File: 7394-79-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-(5-methyl-1H-indol-3-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-methyl-1H-indol-3-yl)propanoic acid(7394-79-8)
• EPA Substance Registry System: 3-(5-methyl-1H-indol-3-yl)propanoic acid(7394-79-8)

Safety Data

• Hazardous Substances Data: 7394-79-8(Hazardous Substances Data)

Upstream product

• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 52562-50-2 5-methylindole-3-carboxaldehyde 
• 1453484-16-6 ethyl 3-(5-methyl-1H-indol-3-yl)propanoate 
• 614-96-0 5-methyl-1H-indole 
• 79-10-7 acrylic acid 

Downstream Products

• 290832-01-8 1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-3-[5-methyl-2-(4-trifluoromethyl-phenyl)-1H-indol-3-yl]-propan-1-one 
• 290831-98-0 3-[2-(4-isopropyl-phenyl)-5-methyl-1H-indol-3-yl]-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propan-1-one 
• 290831-92-4 1-{3-[2-(4-chlorophenyl)-5-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(2-methoxyphenyl)piperazine 
• 290830-49-8 1-{3-[2-(4-bromophenyl)-5-methyl-1H-indol-3-yl]-1-oxopropyl}-4-(2-methoxyphenyl)piperazine 
• 290832-42-7 1-[3-(2-bromo-5-methyl-1H-indol-3-yl)-1-oxopropyl]-4-(2-methoxyphenyl )piperazine 
• 290832-40-5 4-(2-methoxyphenyl) 1-[3-(5-methyl-1H-indol-3-yl)-1-oxopropyl]piperazine 

Relevant articles and documents

Sodium Iodide/Hydrogen Peroxide-Mediated Oxidation/Lactonization for the Construction of Spirocyclic Oxindole-Lactones

The sodium iodide/hydrogen peroxide-mediated oxidation/lactonization of indolepropionic acids was achieved, affording the corresponding spirocyclic oxindole-lactones in moderate to high yields. This metal-free procedure features mild reaction conditions, non-toxicity and easy handling, with hydrogen peroxide (H2O2) as a clean oxidant. (Figure presented.).

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

2-Aryl indole NK1 receptor antagonists: Optimisation of indole substitution

The synthesis and biological evaluation of a series of 2-aryl indoles with high affinity for the human neurokinin-1 (hNK1) receptor are reported, concentrating on optimisation of the indole substitution.