73995-27-4

Basic information

• Product Name: H-Lys-OMe*HCl
• Synonyms: H-Lys-OMe*HCl
• CAS NO: 73995-27-4
• Molecular Weight: 365.257
• Mol File: 73995-27-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: H-Lys-OMe*HCl(CAS DataBase Reference)
• NIST Chemistry Reference: H-Lys-OMe*HCl(73995-27-4)
• EPA Substance Registry System: H-Lys-OMe*HCl(73995-27-4)

Safety Data

• Hazardous Substances Data: 73995-27-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 54613-99-9 Boc-(S)-Lys(2-Cl-Z)-OH 
• 42390-97-6 N^ε-(2-Chlorophenylmethoxycarbonyl)-(S)-lysine 

Downstream Products

• 871815-62-2 (S)-2-[(S)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester 
• 73995-35-4 Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-N2H3 
• 73995-34-3 Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-OMe 
• 73995-31-0 Boc-Pro-Pro-Gln-Lys-OMe 
• 73995-32-1 (S)-2-((S)-4-Carbamoyl-2-{[(S)-1-((S)-pyrrolidine-2-carbonyl)-pyrrolidine-2-carbonyl]-amino}-butyrylamino)-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester 
• 73995-29-6 (S)-2-((S)-2-Amino-4-carbamoyl-butyrylamino)-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester 
• 73995-28-5 Boc-Gln-Lys-OMe 

Relevant articles and documents

A peptide nucleic acid embedding a pseudopeptide nuclear localization sequence in the backbone behaves as a peptide mimic

In this paper, the synthesis of a short modified peptide nucleic acid (PNA), obtained by using several different L-amino acids as synthons, is shown. The synthesis was performed by a submonomeric strategy, obtaining a model trimeric PNA containing embedded amino acid derived side chains in its backbone that mimic the peptide sequence PKKKRKV, which is a nuclear localization signal (NLS) widely used for translocating cargo molecules into cell nuclei. Fluorescence experiments demonstrated that this modified PNA, and not a standard unmodified PNA having the same nucleobase sequence, was able to penetrate Rhabdomyosarcoma cell nuclei, exactly behaving as the NLS standard peptide.