871815-62-2

Basic information

• Product Name: (S)-2-[(S)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester
• CAS NO: 871815-62-2
• Molecular Weight: 711.683
• Mol File: 871815-62-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-[(S)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[(S)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester(871815-62-2)
• EPA Substance Registry System: (S)-2-[(S)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester(871815-62-2)

Safety Data

• Hazardous Substances Data: 871815-62-2(Hazardous Substances Data)

Upstream product

• 73995-27-4 H-Lys-OMe*HCl 
• 166655-48-7 Boc-Lys(N^ε-Z-2-Cl)-aldehyde 
• 54613-99-9 Boc-(S)-Lys(2-Cl-Z)-OH 
• 166655-47-6 [5-tert-butoxycarbonylamino-5-(methoxy-methyl-carbamoyl)-pentyl]-carbamic acid 2-chloro-benzyl ester 
• 191939-79-4 (S)-2-Amino-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester 

Downstream Products

• 871815-68-8 (S)-2-[(S)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid 

Relevant articles and documents

A peptide nucleic acid embedding a pseudopeptide nuclear localization sequence in the backbone behaves as a peptide mimic

In this paper, the synthesis of a short modified peptide nucleic acid (PNA), obtained by using several different L-amino acids as synthons, is shown. The synthesis was performed by a submonomeric strategy, obtaining a model trimeric PNA containing embedded amino acid derived side chains in its backbone that mimic the peptide sequence PKKKRKV, which is a nuclear localization signal (NLS) widely used for translocating cargo molecules into cell nuclei. Fluorescence experiments demonstrated that this modified PNA, and not a standard unmodified PNA having the same nucleobase sequence, was able to penetrate Rhabdomyosarcoma cell nuclei, exactly behaving as the NLS standard peptide.