74626-47-4

Basic information

• Product Name: 1H-INDAZOLE-5-CARBONITRILE
• Synonyms: 1H-Indazole-5-carbonitrile ,97%;5-Cyanoindazole;Indazole-5-carbonitrile;1H-INDAZOLE-5-CARBONITRILE;1H-Indazole-5-carbonitrile(9CI);5-Cyano-1H-indazole
• CAS NO: 74626-47-4
• Molecular Formula: C₈H₅N₃
• Molecular Weight: 143.15
• Product Categories: Building Blocks;Indazole;NITRILE;pharmacetical
• Mol File: 74626-47-4.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 370.312 °C at 760 mmHg
• Flash Point: 126.669 °C
• Appearance: /
• Density: 1.34 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.685
• Storage Temp.: 2-8°C
• PKA: 12.19±0.40(Predicted)
• CAS DataBase Reference: 1H-INDAZOLE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDAZOLE-5-CARBONITRILE(74626-47-4)
• EPA Substance Registry System: 1H-INDAZOLE-5-CARBONITRILE(74626-47-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 74626-47-4(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H5N3/c9-4-6-1-2-8-7(3-6)5-10-11-8/h1-3,5H,(H,10,11)

Upstream product

• 146137-79-3 4-fluoro-3-formylbenzonitrile 
• 19335-11-6 1H-indazol-5-ylamine 
• 544-92-3 copper(I) cyanide 
• 5401-94-5 5-nitroindazole 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 53857-57-1 5-bromo-1H-indazole 
• 557-21-1 dicyanozinc 
• 557-21-1 zinc(II) cyanide 
• 253801-04-6 1H-indazole-5-carbaldehyde 
• 1187245-24-4 C₈H₇N₃O 
• 478828-53-4 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 
• 1173003-54-7 1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carbonitrile 
• 55289-36-6 3-bromo-2-methylaniline 
• 186407-74-9 4-bromoindazole 

Downstream Products

• 61700-61-6 1H-indazole-5-carboxylic acid 
• 267413-25-2 1-(1H-indazol-5-yl)methanamine 
• 395101-67-4 3-bromo-1H-indazole-5-carbonitrile 
• 253801-04-6 1H-indazole-5-carbaldehyde 
• 944898-90-2 3-iodo-1H-indazole-5-carbonitrile 
• 1072947-68-2 5-[3-(1H-indazol-5-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile 
• 1072947-58-0 ethyl 3-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]propanoate 
• 1072946-91-8 3-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]propanoic acid 

Relevant articles and documents

Visible-Light-Mediated N-Desulfonylation of N-Heterocycles Using a Heteroleptic Copper(I) Complex as a Photocatalyst

A photoredox protocol that uses a heteroleptic Cu (I) complex, [Cu(dq)(BINAP)]BF4, has been developed for the photodeprotection of benzenesulfonyl-protected N-heterocycles. A range of substrates was examined, including indazoles, indoles, pyrazoles, and benzimidazole, featuring both electron-rich and electron-deficient substituents, giving good yields of the N-heterocycle products with broad functional group tolerance. This transformation was also found to be amenable to flow reaction conditions.

HISTONE DEMETHYLASE INHIBITORS

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted 3-aminopyridine derivative compounds, substituted 3-aminopyridazine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Oxadiazole substituted indazole derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.