74863-81-3

Basic information

• Product Name: 2-Piperidinecarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl] amino]-1-oxopentyl]-4-methyl-, ethyl ester
• CAS NO: 74863-81-3
• Molecular Formula: C20H36N6O7
• Molecular Weight: 472.542
• Mol File: 74863-81-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Piperidinecarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl] amino]-1-oxopentyl]-4-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinecarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl] amino]-1-oxopentyl]-4-methyl-, ethyl ester(74863-81-3)
• EPA Substance Registry System: 2-Piperidinecarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl] amino]-1-oxopentyl]-4-methyl-, ethyl ester(74863-81-3)

Safety Data

• Hazardous Substances Data: 74863-81-3(Hazardous Substances Data)

Upstream product

• 66937-93-7 4(R)-Methylpiperidine-2(R)-carboxylic acid ethyl ester 
• 2188-18-3 Boc-Arg(NO₂)-OH 

Downstream Products

• 69129-28-8 ethyl 4-methyl-1-(N^ω-nitro-L-arginyl)piperidinecarboxylate hydrochloride 

Relevant articles and documents

Thrombin inhibitors. 3. Carboxyl-containing amide derivatives of N alpha-substituted L-arginine.

A series of N alpha-(arylsulfonyl)-L-arginine amide derivatives having carboxamide N-substituents with a carboxyl group was prepared and tested as inhibitors of the clotting activity of thrombin. The most inhibitory compounds were obtained when a carboxyl group was introduced into the carbon next to the amide nitrogen of N alpha-(arylsulfonyl)-L-arginine amide derivatives, e.g., N alpha-(arylsulfonyl)-L-arginyl-N-butyl-, N-(methoxyethyl)- or N-(tetrahydrofurfuryl)glycine and 4-alkyl-1-[N alpha-(arylsulfonyl)-L-arginyl]-2-piperidinecarboxylic acid, with an I50 of 1-3 X 10(-7) M.