75001-09-1Relevant articles and documents
Preparation method of precursor raw material Pht-AEEA-AEEA for somatostatin side chain
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Paragraph 0047; 0057-0059; 0083; 0093-0095; 0119; 0129-0131, (2021/10/05)
The preparation method comprises the following steps: in the reaction kettle, adding AEEA phthalic AEEA anhydride, toluene, opening stirring, heating and refluxing, separating the 100 ml water Pht through a water separator, ending the reaction, and lowering the temperature to room temperature. Post-treatment: addition of saturated NaHCO3 The solution was washed 1h. The method is scientific and reasonable in structure, safe and convenient to use, and safe and convenient to use; the product is prepared by using @timetime@ petroleum ether 1:20, AEEA-AEEA ethyl ester as a raw material, PA-AEEA - ethyl ester preparation third and deamination, and then PA ethyl ester is prepared by using the solid phase method AEEA AEEA . 4th-Pht-AEEA Ethyl AEEA -ethyl ester.
Synthesis of novel amphiphilic spin probes with the paramagnetic doxyl group in the polar region
Pajk, Stane,Pe?ar, Slavko
scheme or table, p. 659 - 665 (2009/04/07)
The use of ESR and specially designed spin probes has led to major breakthroughs in understanding the complexity of biological membranes. Research has been focused mainly on molecular events within the?lipid bilayer, and few probes have been designed for studying events in the extracellular space near the membrane surface. We have prepared a series of amphiphilic spin probes in which an ethylene glycol type hydrophilic spacer was introduced between a hydrophobic anchor and the doxyl group, placing the latter above the membrane in the extracellular space. Furthermore, the 2pπ orbital, containing the unpaired electron of the nitroxide group, would be orientated perpendicular to the membrane surface, making it more useful for ESR investigations of structural and dynamic properties close to the membrane surface in different situations of the cell life.
THE SYNTHESIS OF GLYCOLIPIDS CONTAINING A HYDROPHILIC SPACER-GROUP
Slama, James,Rando, Robert R.
, p. 213 - 222 (2007/10/02)
Cholesterol-containing glycolipids incorporating a new hydrophilic specer-group, 8-amino-3,6-dioxaoctanoic acid, were synthesized.This spacer group eliminates many of the problems inherent in the use of hydrophobic or charged, spacer arms.