76985-08-5

Basic information

• Product Name: 2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID
• Synonyms: (RS)-2-AMINO-3-(4-BIPHENYL)PROPIONIC ACID;DL-BIPHENYLALANINE;2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID;4-Phenyl-DL-Phenylalanine;DL-4-Phenyl-Phe-OH;alpha-Amino-(1,1'-biphenyl)-4-propanoic acid;2-AMino-3-(4-biphenylyl)propanoic Acid;DL-4-Phenyl-Phe-OH 4-Phenyl-DL-Phenylalanine
• CAS NO: 76985-08-5
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.29
• Mol File: 76985-08-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 428.6 °C at 760 mmHg
• Flash Point: 213 °C
• Appearance: white crystalline powder
• Density: 1.19 g/cm³
• Vapor Pressure: 4.15E-08mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID(76985-08-5)
• EPA Substance Registry System: 2-AMINO-3-BIPHENYL-4-YL-PROPIONIC ACID(76985-08-5)

Safety Data

• Hazardous Substances Data: 76985-08-5(Hazardous Substances Data)

Usage

General Description

2-Amino-3-biphenyl-4-yl-propionic acid is a chemical compound that consists of a biphenyl group attached to a propionic acid group with an amino group at the 2 position of the biphenyl ring. It is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. This chemical is a white to pale yellow crystalline powder with a molecular formula of C17H15NO2 and a molecular weight of 277.31 g/mol. It is known for its potential applications in the field of medicinal chemistry, particularly in the development of drugs for various medical conditions.

InChI:InChI=1/C15H15NO2/c16-14(15(17)18)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,14H,10,16H2,(H,17,18)

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 98-80-6 phenylboronic acid 
• 3218-36-8 4-Phenylbenzaldehyde 
• 38913-04-1 ethyl 3-([1,1'-biphenyl]-4-yl)-2-cyanoacrylate 
• 2567-29-5 p-phenylbenzyl bromide 

Downstream Products

• 515158-71-1 methyl 3-([1,1‘-biphenyl]-4-yl)-2-aminopropanoate 
• 13026-23-8 (2E)-3-(1,1'-biphenyl-4-yl)acrylic acid 
• 170080-13-4 ([1,1’-biphenyl]-4-yl)alanine 
• 155760-02-4 (S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid 

Relevant articles and documents

Preparation method for 2-amino-3-biphenylpropionic acid

The invention discloses a preparation method for 2-amino-3-biphenylpropionic acid. The preparation method comprises the following steps: step 1, with p-bromobenzaldehyde and phenylboronic acid as rawmaterials and an organic solvent as a reaction solvent, subjecting the p-bromobenzaldehyde and the phenylboronic acid to a reaction under the actions of alkali and a catalyst so as to obtain biphenylcarbaldehyde (II); step 2, allowing the biphenylcarbaldehyde (II) to react with ethyl cyanoacetate under the action of the alkali so as to obtain an intermediate (III); step 3, allowing the intermediate (III) to generate a reduction reaction with hydrogen under the catalytic action of Pd/C in a hydrogen atmosphere so as to obtain an intermediate (IV); step 4, allowing the intermediate (IV) to be hydrolyzed into an amide compound (V) in absolute ethyl alcohol under the action of the alkali; and step 5, subjecting the amide compound (V) to a reaction under the actions of bromine and sodium hydroxide so as to obtain the 2-amino-3-biphenylpropionic acid. The preparation method provided by the invention has the advantages of cheap and easily-available raw materials, low production cost, short reaction steps, mild reaction conditions, convenient post-treatment, high yield and applicability to industrial production.