77302-66-0

Basic information

• Product Name: (R)-2-((S)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-methyl-pentanoic acid methyl ester; hydrochloride
• CAS NO: 77302-66-0
• Molecular Weight: 400.903
• Mol File: 77302-66-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-2-((S)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-methyl-pentanoic acid methyl ester; hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-((S)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-methyl-pentanoic acid methyl ester; hydrochloride(77302-66-0)
• EPA Substance Registry System: (R)-2-((S)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-methyl-pentanoic acid methyl ester; hydrochloride(77302-66-0)

Safety Data

• Hazardous Substances Data: 77302-66-0(Hazardous Substances Data)

Upstream product

• 13574-13-5 Boc-Glu(OBzl)-OH 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 2666-93-5 (S)-Leu-OMe 
• 7536-59-6 Boc-Glu(OBzl)-ONp 
• 5845-53-4 (R)-leucine methyl ester hydrochloride 
• 62324-33-8 (R)-2-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-4-methyl-pentanoic acid methyl ester 

Downstream Products

• 70681-16-2 cyclo(4-benzyl-L-Glu-L-Leu) 
• 131697-02-4 Boc-Ser-Glu-Leu-Lys(Z)-Ser-Phe-Pro-OMe 
• 72903-33-4 N-(tert-butoxycarbonyl)-L-glutamyl-L-glutamyl-L-leucine methyl ester 
• 77302-71-7 N-(tert-butoxycarbonyl)-L-phenylalanyl-L-leucyl-L-γ-O-benzylglutamyl-L-γ-O-benzylglutamyl-L-leucine methyl ester 
• 77302-97-7 (S)-2-((S)-4-Benzyloxycarbonyl-2-{(R)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester 
• 77302-70-6 (S)-2-{(S)-2-[(R)-2-((S)-2-Amino-4-methyl-pentanoylamino)-4-benzyloxycarbonyl-butyrylamino]-4-benzyloxycarbonyl-butyrylamino}-4-methyl-pentanoic acid methyl ester; hydrochloride 
• 77302-70-6 (S)-2-{(S)-2-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-4-benzyloxycarbonyl-butyrylamino]-4-benzyloxycarbonyl-butyrylamino}-4-methyl-pentanoic acid methyl ester; hydrochloride 
• 72903-31-2 N-(tert-butoxycarbonyl)-L-phenylalanyl-L-leucyl-L-glutamyl-L-glutamyl-L-leucine methyl ester 
• 72903-44-7 Boc-Phe-Leu-D-Glu-Glu-Leu-OMe 
• 77302-69-3 N-(tert-butoxycarbonyl)-L-leucyl-L-γ-O-benzylglutamyl-L-γ-O-benzylglutamyl-L-leucine methyl ester 
• 77302-69-3 (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(R)-4-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-4-methyl-pentanoic acid methyl ester 
• 77302-94-4 (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((R)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-4-methyl-pentanoic acid methyl ester 
• 77302-68-2 (S)-2-[(S)-2-((S)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-benzyloxycarbonyl-butyrylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride 
• 77302-68-2 (S)-2-[(S)-2-((R)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-benzyloxycarbonyl-butyrylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride 

Relevant articles and documents

Cyclic dipeptides exhibit potency for scavenging radicals

Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against .OH and O2·- was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against .OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O2·-.

Synthesis of Peptide Analogues of Prothrombin Precursor Sequence 5-9. Substrate Specificity of Vitamin K Dependent Carboxylase

Thirty-five analogues of Phe-Leu-Glu-Glu-Leu, the pentapeptide sequence 5-9 of bovine prothrombin precursor, were synthesized and assayed as potential substrates or inhibitors of rat liver vitamin K dependent carboxylase.Carboxylation of substrate was determined by measuring the incorporation of carbon-14 labeled bicarbonate into product.Changes in substrate carboxylation produced by changing peptide chain length, amino acid chirality, or the distance seperating the peptide chain backbone from the carboxyl group were measured.The data suggest that the carboxylase carboxylates L-glutamic acid residues and does not carboxylate L-aspartic acid, L-homoglutamic acid, glutamine, or D-glutamic acid residues; tri- through pentapeptides are better substrates than mono- or bis(amino acid) derivatives, and hydrophobic groups added to the N-terminus can produce better substrates for the enzyme.None of the synthetic substrates is carboxylated as effectively as the endogenous protein substrates for the enzyme.The effect of structure on additional parameters affecting carboxylation is discussed.