773873-95-3

Basic information

• Product Name: methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate
• Synonyms: methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate;1,3-Benzodioxole-5-carboxylic acid, 2,2-difluoro-, Methyl ester;2,2-Difluorobenzodioxole-5-carboxylic acid Methyl ester;2,2-Difluoro-benzo[1,3]dioxole-5-carboxylic acid methyl ester;Methyl 2,2-difluoro-1,3-benzodioxole-5-carboxylate;Methyl 3,4-(difluoromethylenedioxy)benzoate, 2,2-Difluoro-5-(methoxycarbonyl)-1,3-benzodioxole;EOS-61003
• CAS NO: 773873-95-3
• Molecular Formula: C₉H₆F₂O₄
• Molecular Weight: 216.1383464
• Mol File: 773873-95-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 227.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.47±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate(773873-95-3)
• EPA Substance Registry System: methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate(773873-95-3)

Safety Data

• Hazardous Substances Data: 773873-95-3(Hazardous Substances Data)

Usage

Uses

Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate is a useful research chemical.

Upstream product

• 67-56-1 methanol 
• 33070-32-5 5-bromo-2,2-difluoro-2H-1,3-benzodioxole 
• 201230-82-2 carbon monoxide 
• 120-57-0 piperonal 
• 656-46-2 2,2-difluoro-1,3-benzodioxole-5-carboxylic acid 

Downstream Products

• 72768-97-9 (2,2-difluoro-1,3-benzodioxol-5-yl)methanol 
• 476473-97-9 5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole 
• 68119-31-3 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 
• 656-46-2 2,2-difluoro-1,3-benzodioxole-5-carboxylic acid 
• 862574-88-7 1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid 
• 862574-87-6 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile 
• 1160221-25-9 tert-butyl 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoate 
• 1160221-26-0 Lumacaftor hydrochloride 
• 1294504-68-9 N-{1-[(2R)-3-(benzyloxy)-2-hydroxypropyl]-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-5-yl}-1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamide 
• 1152311-62-0 (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide 
• 1083168-23-3 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide 
• 1083168-21-1 N-(6-(1-(2-cyanamido-2-oxoethyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide 
• 1152274-56-0 3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride 
• 1152274-47-9 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(4-(hydroxymethyl)phenyl)isoquinolin-3-yl)cyclopropanecarboxamide 

Relevant articles and documents

A 2, 2 - difluoro pepper acid methyl ester preparation method

The invention discloses a preparation method of methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate. The method comprises the steps of performing cyanation reaction to 5-bromo-2,2-difluoro-1,3-benzodioxole and cuprous cyanide, then performing hydrolysis to form acid, and then performing esterification to obtain 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate. In the preparation method disclosed by the invention, by using 5-bromo-2,2-difluoro-1,3-benzodioxole as a start raw material, performing cyanation by using low-toxicity cuprous cyanide, then performing hydrolysis to form acid and performing methanol reaction esterification to obtain the product, the process flow of the method is simple and the reaction process is easy to control. In the reaction process, the purification of the intermediate product produced in each step does not need a complex purification process, the purification process is simple, the purification yield is high, the entire process flow is simple and high-efficiency, the product yield is high, the cost of the entire flow is low and the preparation method is very suitable for large-scale industrial production.

CYCLOPROPANECARBOXAMIDE MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

The present invention relates to new cyclopropanecarboxamide modulators of cystic fibrosis transmembrane conductance regulator proteins, pharmaceutical compositions thereof, and methods of use thereof.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.