78761-29-2

Basic information

• Product Name: (R)-Acetylamino-(S)-cyclohex-2-enyl-acetic acid 2-acetylamino-2-phenyl-ethyl ester
• CAS NO: 78761-29-2
• Molecular Weight: 358.437
• Mol File: 78761-29-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-Acetylamino-(S)-cyclohex-2-enyl-acetic acid 2-acetylamino-2-phenyl-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Acetylamino-(S)-cyclohex-2-enyl-acetic acid 2-acetylamino-2-phenyl-ethyl ester(78761-29-2)
• EPA Substance Registry System: (R)-Acetylamino-(S)-cyclohex-2-enyl-acetic acid 2-acetylamino-2-phenyl-ethyl ester(78761-29-2)

Safety Data

• Hazardous Substances Data: 78761-29-2(Hazardous Substances Data)

Upstream product

• 56613-80-0 D-(-)-2-amino-2-phenyl-1-ethanol 
• 62090-88-4 2-(2'-Cyclohexenyl)glycin 

Downstream Products

• 78781-84-7 (S)-2-acetamido-2-cyclohexylacetic acid 
• 78761-31-6 (-)-(2R,1'S)-N-Acetyl-2-(2'-cyclohexenyl)glycin 
• 78919-35-4 (+)-(2R,1'R)-N-Acetyl-2-(2'-cyclohexenyl)glycin 
• 78761-30-5 (-)-(2S,1'S)-N-Acetyl-2-(2'-cyclohexenyl)glycin 

Relevant articles and documents

On Amino Acid Antagonists,IV.-Separation and Determination of the Configurations of the Stereoisomeric N-Acetyl-2-(2'-cyclohexenyl)glycines

The D-(+)-(1-phenylethyl)amides 5 as well as the D-(-)-O-acetyl-α-phenylglycinolamides 7 of the title compounds were separated on silica gel into the four diastereomeric compounds.All attempts failed to hydrolyze 5 and 7 to the corresponding acids.In contrast the diastereomeric D-(-)-N-acetyl-α-phenylglycinol esters 10 which were separated on silica gel were hydrolysed to the optically active acids 3a-d.The absolute configurations at C-2 in 3 were determined by correlation with the saturated glycine derivatives of known stereochemistry.The relative configurationsand hence the absolute configurations at C-1' in 3a-d were deduced from the NMR- and CD-spectra and were confirmed by X-ray analysis of 3a.Only the amino acid 3b with the (2S,1'R)-configuration exhibits biological activity.