78781-84-7

Basic information

• Product Name: (S)-ACETYLAMINO-CYCLOHEXYL-ACETIC ACID
• Synonyms: (S)-ACETYLAMINO-CYCLOHEXYL-ACETIC ACID;(S)-2-Acetamido-2-cyclohexylaceticacid
• CAS NO: 78781-84-7
• Molecular Formula: C₁₀H₁₇NO₃
• Molecular Weight: 199.25
• Mol File: 78781-84-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 428.641 °C at 760 mmHg
• Flash Point: 213.035 °C
• Appearance: /
• Density: 1.134 g/cm³
• CAS DataBase Reference: (S)-ACETYLAMINO-CYCLOHEXYL-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-ACETYLAMINO-CYCLOHEXYL-ACETIC ACID(78781-84-7)
• EPA Substance Registry System: (S)-ACETYLAMINO-CYCLOHEXYL-ACETIC ACID(78781-84-7)

Safety Data

• Hazardous Substances Data: 78781-84-7(Hazardous Substances Data)

Usage

General Description

(S)-Acetylamino-cyclohexyl-acetic acid, also known as aceclofenac, is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain and inflammation in conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It works by inhibiting the production of prostaglandins, which are chemicals that play a key role in causing pain and inflammation in the body. This medication is available in various forms such as tablets, capsules, and topical gels, and is typically taken orally. It is important to use this medication as directed by a healthcare professional and to be aware of potential side effects and interactions with other medications.

Upstream product

• 78761-32-7 (+)-(2S,1'R)-N-Acetyl-2-(2'-cyclohexenyl)glycin 
• 78761-30-5 (-)-(2S,1'S)-N-Acetyl-2-(2'-cyclohexenyl)glycin 
• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 2043-61-0 cyclohexanecarbaldehyde 
• 32908-43-3 (-)-(S)-N-(cyclohexylphenylmethyl)acetamide 
• 169698-50-4 (E)-N-(cyclohexylmethylene)-4-methoxyphenylamine 
• 326894-40-0 (S)-(-)-N-[cyclohexyl(phenyl)methyl]-N-(4-methoxyphenyl)amine 
• 78761-26-9 N-[(1R)-2-hydroxy-1-phenylethyl]acetamide 
• 56613-80-0 D-(-)-2-amino-2-phenyl-1-ethanol 
• 78761-29-2 (S)-Acetylamino-(R)-cyclohex-2-enyl-acetic acid 2-acetylamino-2-phenyl-ethyl ester 
• 78761-29-2 (S)-Acetylamino-(S)-cyclohex-2-enyl-acetic acid 2-acetylamino-2-phenyl-ethyl ester 
• 1233234-93-9 2-acetamido-2-cyclohexylideneacetic acid 
• 168169-14-0 C₂HF₃O₂*C₈H₁₅NO₂ 

Relevant articles and documents

GRANZYME B DIRECTED IMAGING AND THERAPY

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

Impact on hydrogenation catalytic cycle of the R groups Cyclic feature in "r-SMS-Phos"

A series of R-SMS-Phos ligands was evaluated in the Rh(I)-catalyzed hydrogenation of a set of olefins showing a marked influence of the cyclic nature and structure of the R groups. Overall, cPen- and Cy-SMS-Phos performed efficiently, while Ph- and Bn-SMS-Phos exhibited slower kinetics and furnished lower ees also compared with C6F5CH2-SMS-Phos. The Rh(I)-(Cy-SMS-Phos) catalyst was screened under mild conditions displaying excellent enantioselectivities and high TOFs. Cases of catalysis under catalyst or substrate control were identified.

Efficient chemoenzymatic synthesis of enantiomerically pure α-amino acids

A general two-step chemoenzymatic synthesis for enantiomerically pure natural and nonnatural α-amino acids is presented. In the first step of the sequence, the ubiquitous educts aldehyde, amide and carbon monoxide react by palladium-catalyzed amidocarbonylation to afford the racemic N-acyl amino acids in excellent yields. In the second step, enzymatic enantioselective hydrolysis yields the free optically pure a-amino acid and the other enantiomer as the N-acyl derivative, both in optical purities of 85-99.5% ee. The advantage of the chemoenzymatic process compared to other amino acid synthesis are demonstrated by the preparation of various functionalized (-OR, -Cl, -F, -SR) α-amino acids on a 10-g scale.