79456-26-1Relevant articles and documents
Method for synthesizing 2-amino-3-chloro-5-trifluoromethylpyridine
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Paragraph 0007; 0020; 0023-0025; 0026; 0029-0031; 0032-0037, (2021/02/06)
The invention discloses a method for synthesizing 2-amino-3-chloro-5-trifluoromethylpyridine, and belongs to the technical field of organic synthesis. Specifically, starting from 2-aminopyridine, three chemical reactions of bromination, chlorination and coupling are involved, and two organic solvents are used in the whole process; and after the three-step reaction, recrystallization treatment is carried out to obtain the high-purity 2-amino-3-chloro-5-trifluoromethylpyridine. The method is mild in reaction condition and easy to control, and the obtained product is high in purity; reaction rawmaterials and organic solvents are easy to obtain and low in price, and a new way is provided for large-scale production.
Method for preparing 2-amino-3-chloro-5-trifluoromethylpyridine
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Paragraph 0007; 0016; 0018-0019; 0021-0022; 0024-0025; 0027, (2020/09/09)
The invention belongs to the technical field of pesticide intermediate synthesis, and relates to a method for preparing 2-amino-3-chloro-5-trifluoromethylpyridine. According to the method, 2, 3, 6-trichloro-5-trifluoromethylpyridine is used as a raw material, and amination and reduction reaction are performed to obtain the 2-amino-3-chloro-5-trifluoromethylpyridine. The byproduct 2, 3, 6-trichloro-5-trifluoromethylpyridine in a 2, 3-dichloro-5-trifluoromethylpyridine production process is used as the raw material to prepare the 2-amino-3-chloro-5-trifluoromethylpyridine, the synthesis cost ofthe 2-amino-3-chloro-5-trifluoromethylpyridine can be effectively reduced, and the purity of an obtained product meets the use requirements of industrial production.
Synthetic process of fluazinam
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Paragraph 0025-0026; 0029-0030; 0039-0040; 0043-0044, (2019/08/31)
The invention discloses a synthetic process of fluazinam, and belongs to the technical field of pesticide chemical engineering. The process comprises the following steps: taking 2-halogen-3-chloro-5-trifluoromethyl pyridine and ammonia gas as raw materials to carry out an amination reaction in an ether solvent in a high-pressure kettle, carrying out desalination and deamination on the reaction liquid, then carrying out a condensation reaction with 2,4-dichloro-3,5-binitro-trifluorotoluene under an alkaline condition, and carrying out a conventional post-treatment method to obtain the fluazinam. According to the invention, in a continuous process of the two-step process, generation of side reactions of 2,4-dichloro-3,5-binitro-trifluorotoluene during the condensation reaction due to ammoniaresidues in an amine solution is avoided, so that unit consumption of the 2,4-dichloro-3,5-binitro-trifluorotoluene is reduced to a stoichiometric ratio, and product purification and yield are greatly improved. The product does not need to be purified, the purity can reach 99% or above, and the total separation yield of two steps can reach 97% or above.