74784-70-6

Basic information

• Product Name: 5-(Trifluoromethyl)pyridin-2-amine
• Synonyms: 2-Amino-5-(trifluoromethyl)pyridine 95%;2-Amino-5-(trifluoromethyl)pyridine95%;2-pyridinamine,5-(triflluoromethyl;2-Amine-5-Trifluromethyl Pyridine;5-(Trifluoromethyl)pyridin-2-amine ,97%;5-(trifluoromethyl)pyridine-2-amine;2-Amino-5-Trifluoromethyl Pyridine ,98%;2-Amino-5-(trifluoromethy...
• CAS NO: 74784-70-6
• Molecular Formula: C₆H₅F₃N₂
• Molecular Weight: 162.11
• EINECS: -0
• Product Categories: Amines and Anilines;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Amines;Pyridines;Pyridine;C6;Heterocyclic Building Blocks;Fluorine series;amine
• Mol File: 74784-70-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 45 °C
• Boiling Point: 90-92/20mbar
• Flash Point: 104 °C
• Appearance: /
• Density: 1,71g/cm
• Vapor Pressure: 0.217mmHg at 25°C
• Refractive Index: 1,533
• Storage Temp.: Room temperature.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.55±0.13(Predicted)
• BRN: 4800784
• CAS DataBase Reference: 5-(Trifluoromethyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Trifluoromethyl)pyridin-2-amine(74784-70-6)
• EPA Substance Registry System: 5-(Trifluoromethyl)pyridin-2-amine(74784-70-6)

Safety Data

• Hazard Codes: Xn,Xi,T
• Statements: 20/21/22-36/37/38-25
• Safety Statements: 26-36/37/39-45-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 74784-70-6(Hazardous Substances Data)

Usage

Description

5-(Trifluoromethyl)pyridin-2-amine is an organic compound that features a pyridine ring with a trifluoromethyl group at the 5th position and an amino group at the 2nd position. 5-(Trifluoromethyl)pyridin-2-amine is known for its potential applications in medicinal chemistry and pharmaceutical research.

Uses

Used in Pharmaceutical Industry:
5-(Trifluoromethyl)pyridin-2-amine is used as a reagent for the synthesis of selective inhibitors of urokinase plasminogen activator. This application is significant in the development of non-cytotoxic forms of cancer therapy, offering a promising approach to target and inhibit specific enzymes involved in cancer progression without harming healthy cells.

InChI:InChI=1/C6H5F3N2/c7-6(8,9)4-1-2-5(10)11-3-4/h1-3H,(H2,10,11)

Upstream product

• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 
• 573676-20-7 (5-trifluoromethylpyridin-2-yl)-[7-(3-trifluoromethylpyridin-2-yl)quinazolin-4-yl]amine 

Downstream Products

• 79456-26-1 2-amino-3-chloro-5-(trifluoromethyl)pyridine 
• 118000-42-3 2-(chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine 
• 53359-69-6 5-(Trifluoromethyl)-3-nitro-2-aminopyridine 
• 79456-30-7 3-bromo-5-trifluoromethyl-pyridin-2-ylamine 
• 95651-19-7 (5-Trifluoromethyl-pyridin-2-yl)-carbamic acid phenyl ester 
• 913198-20-6 4-(5-(trifluoromethyl)pyridin-2-ylcarbamoyl)phenylboronic acid 
• 107867-51-6 5-(trifluoromethyl)-2,3-pyridinediamine 
• 202409-73-2 2-amino-3-[4-(methylthio)phenyl]-5-trifluoromethyl-pyridine 
• 202409-74-3 2-amino-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine 
• 202409-76-5 2-bromo-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine 
• 202409-75-4 2-chloro-3-[4-(methylsulfonyl)phenyl]-5-trifluoromethyl-pyridine 

Relevant articles and documents

PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS

The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).

SOME NEW 2-SUBSTITUTED 5-TRIFLUOROMETHYLPYRIDINES

The preparation of the derivatives of 2-amino-, hydrazino-, hydroxy-, and mercapto-5-trifluoromethylpyridines via 2-chloro precursors is describes.Experimental and spectral data of the products together with those of the precursors are presented.