80100-23-8

Basic information

• Product Name: 2-Chloro-alpha-phenyl-3-pyridinemethanol
• Synonyms: 2-Chloro-alpha-phenyl-3-pyridinemethanol
• CAS NO: 80100-23-8
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.67
• Mol File: 80100-23-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 381.6°C at 760 mmHg
• Flash Point: 184.6°C
• Appearance: /
• Density: 1.275g/cm³
• Vapor Pressure: 1.67E-06mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 2-Chloro-alpha-phenyl-3-pyridinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-alpha-phenyl-3-pyridinemethanol(80100-23-8)
• EPA Substance Registry System: 2-Chloro-alpha-phenyl-3-pyridinemethanol(80100-23-8)

Safety Data

• Hazardous Substances Data: 80100-23-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H10ClNO/c13-12-10(7-4-8-14-12)11(15)9-5-2-1-3-6-9/h1-8,11,15H

Upstream product

• 109-09-1 2-chloropyridine 
• 100-52-7 benzaldehyde 
• 78607-36-0 2-chloro-3-iodopyridine 
• 80099-81-6 3-benzoyl-2-chloro-pyridine 
• 36404-88-3 2-chloro-3-carbaldehydepyridine 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 80099-81-6 3-benzoyl-2-chloro-pyridine 
• 3810-10-4 2-amino-3-benzoylpyridine 
• 130277-16-6 2-amino-3-benzylpyridine 
• 125867-44-9 5-phenyl-6,7,8,9-tetrahydrobenzo<1,8>naphthiridine 
• 1357305-92-0 3-(phenyl-2-chloropyrid-3-ylmethoxy)azetidine 
• 1357305-36-2 2-chloro-3-[phenyl({1-[(piperidin-1-yl)carbonyl]azetidin-3-yl}oxy)methyl]pyridine 

Relevant articles and documents

Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity

We describe here our attempts to optimise the human fatty acid amide hydrolase (FAAH) inhibition and physicochemical properties of our previously reported tetrasubstituted azetidine urea FAAH inhibitor, VER-156084. We describe the SAR of a series of analogues and conclude with the demonstration of in vivo dose-dependant FAAH inhibition in an anandamide-loading study in rats.

Preparation of highly functionalized pyridylmagnesium reagents for the synthesis of polyfunctional pyridines

Functionalized iodopyridines bearing either a chloride, ester or nitrile function were converted to the corresponding organomagnesium derivatives at -40°C or -78°C by treatment with i-PrMgBr (1.1 equiv, 0.5 h, > 90% yield). The resulting functionalized Grignard reagents react with aldehydes, TosCN directly or with allylic bromides and benzoyl chloride after transmetalation with CuCN leading to polyfunctional pyridines.

Improved Synthesis of 2,3-Disubstituted Pyridines by Metallation of 2-Chloropyridine: a Convenient Route to Fused Polyheterocycles

Chemoselective directed metallation of 2-chloropyridine allows the synthesis of 2-substituted 3-carbonylated pyridines, advantage being taken of the metallation ortho-directing effect of the halogen, as well as its reactivity towards nucleophiles.Thus (2-chloro-, 2-methoxy-, and 2-amino-3-pyridyl)-ethanones and -arylmethanones as well as carbaldehydes have been prepared.Some of these ortho-disubstituted intermediates have been readily cyclized to fused polyheterocycles such as naphthiridines and aza-analoges of coumarins, xanthones, and acridones.