80457-61-0Relevant articles and documents
New glucocerebrosidase inhibitors by exploration of chemical diversity of N -substituted aminocyclitols using click chemistry and in situ screening
Díaz, Lucía,Casas, Josefina,Bujons, Jordi,Llebaria, Amadeu,Delgado, Antonio
supporting information; experimental part, p. 2069 - 2079 (2011/06/10)
A library of aminocyclitols derived from CuAAC reaction between N-propargylaminocyclitol 4 and a series of azides [1′25] is described and tested against GCase. Azides have been chosen from a large collection of potential candidates that has been filtered
The first total synthesis of SB87-Cl and pestalone, novel bioactive benzophenone natural products
Iijima, Daisuke,Tanaka, Daisuke,Hamada, Motoko,Ogamino, Takahisa,Ishikawa, Yuichi,Nishiyama, Shigeru
, p. 5469 - 5471 (2007/10/03)
SB87-Cl 1, an inhibitor of testosterone-5α-reductase, and pestalone 2 exhibiting effective antimicrobial activity against MRSA (MIC=37ng/mL) and VRE (MIC=78ng/mL), were novel bioactive benzophenone natural products. Total synthesis of 1 and 2 has been successfully accomplished. The common synthetic precursor 18 of 1 and 2, was successfully obtained by the coupling of 8 with 12.
Mechanistic studies on the biomimetic reduction of tetrahydroxynaphthalene, a key intermediate in melanin biosynthesis
Ichinose,Ebizuka,Sankawa
, p. 192 - 196 (2007/10/03)
1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an aromatic polyketide, serving as a general precursor of fungal melanin. Melanin biosynthesis involves two consecutive deoxygenations of T4HN, consisting of the reduction of a phenolic carbon followed by dehydrat