81148-15-4 Usage
Description
ALS 8123, also known as Esmolol Acid, is a carboxylic acid that is 3-phenylpropanoic acid substituted at position 4 by a 2-hydroxy-3-(propan-2-ylamino)propoxy group. It is the major metabolite of Esmolol (E668000), a cardioselective β-adrenergic blocker with antiarrhythmic properties.
Uses
Used in Pharmaceutical Industry:
ALS 8123 is used as an active pharmaceutical ingredient for the development of medications with antiarrhythmic properties. Its cardioselective β-adrenergic blocking action helps in the management and treatment of various cardiac conditions, such as arrhythmias and hypertension.
Used in Research and Development:
ALS 8123 serves as a valuable compound in research and development for studying the mechanisms of action and potential therapeutic applications of β-adrenergic blockers. This knowledge can contribute to the discovery of new drugs and treatment strategies for cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 81148-15-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,1,4 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 81148-15:
(7*8)+(6*1)+(5*1)+(4*4)+(3*8)+(2*1)+(1*5)=114
114 % 10 = 4
So 81148-15-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H23NO4/c1-11(2)16-9-13(17)10-20-14-6-3-12(4-7-14)5-8-15(18)19/h3-4,6-7,11,13,16-17H,5,8-10H2,1-2H3,(H,18,19)
81148-15-4Relevant articles and documents
Hitting a soft drug with a hard nucleophile: Preparation of esmolol's metabolite by treatment with bis(tributyltin) oxide
Zhang, Cunyu A.,Erhardt, Paul W.
experimental part, p. 722 - 726 (2012/01/13)
A facile method for the production of esmolol's metabolite in high purity is described. Bis(tributyltin) oxide is used to disrupt esmolol's ester linkage, and hydrolysis is completed by addition of water, which also allows the inorganic side products to be conveniently extracted into ether. Evaporation of the aqueous phase and trituration with ethyl acetate provides the carboxylic acid-amine internal salt as a white, free-flowing powder. Taylor & Francis Group, LLC.
Ultra-Short-Acting β-Adrenergic Receptor Blocking Agents. 2. (Aryloxy)propanolamines Containing Esters on the Aryl Function
Erhardt, Paul W.,Woo, Chi M.,Anderson, William G.,Gorczynski, Richard J.
, p. 1408 - 1412 (2007/10/02)
Several short-acting β-adrenergic receptor blocking agents have been prepared by incorporating ester functions into the aryl portion of certain (aryloxy)propanolamine systems.In particular, methyl 3-phenyl>propionate hydrochloride (ASL-8052) was found to be a moderately potent, cardioselective compound with a short duration of action when determined in in vivo canine models.