81506-23-2

Basic information

• Product Name: <3S-(1E,3α,5β)>-<3,5-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic acid ethyl ester
• Synonyms: <3S-(1E,3α,5β)>-<3,5-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic acid ethyl ester
• CAS NO: 81506-23-2
• Molecular Weight: 440.771
• Mol File: 81506-23-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: <3S-(1E,3α,5β)>-<3,5-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: <3S-(1E,3α,5β)>-<3,5-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic acid ethyl ester(81506-23-2)
• EPA Substance Registry System: <3S-(1E,3α,5β)>-<3,5-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic acid ethyl ester(81506-23-2)

Safety Data

• Hazardous Substances Data: 81506-23-2(Hazardous Substances Data)

Upstream product

• 127491-99-0 (1RS,3S,5R)-3,5-bis(t-butyldimethylsiloxy)-1-carboethoxymethyl-2-methylenecyclohexane 
• 137609-91-7 (E)-(R)-8-Bromo-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-nona-2,8-dienoic acid ethyl ester 
• 137609-91-7 (+)-ethyl (5S,7S)-5,7-bis(t-butyldimethylsiloxy)-8-bromonona-2E,8-dienoate 
• 137693-94-8 [(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methylene-cyclohex-(E)-ylidene]-acetic acid ethyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 81506-22-1 <2S-(1E,2α,3β,5α)>-<3,5-bis<<(1,1dimethylethyl)dimethylsilyl>oxy>-2-hydroxy-2-methylcyclohexylidene>acetic acid ethyl ester 
• 161055-43-2 (5R,7S)-5,7-Bis-(tert-butyl-dimethyl-silanyloxy)-non-8-en-2-ynoic acid ethyl ester 
• 75-03-6 ethyl iodide 
• 594-19-4 tert.-butyl lithium 
• 331732-28-6 ethyl [3S-(1E,3α,5β)]-[3,5-bis[[(1,1-dimethylethyl)dimethylsily]oxy]-2-methylenecyclohexylidene](phenylsulfinyl)acetate 
• 442518-51-6 ethyl 2-[(1S,4S,6S)-1-methyl-7-oxa-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-bicyclo[4.1.0]hept-2-ylidene]acetate 
• 2244-16-8 (S)-p-mentha-6,8-dien-2-one 
• 39903-97-4 (S)-carvone oxide 
• 326496-91-7 (1S,4S,6S)-4-Hydroxy-1-methyl-7-oxa-bicyclo[4.1.0]heptan-2-one 

Downstream Products

• 81570-20-9 <3S-(1Z,3α,5β)>-<3,5-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic acid ethyl ester 
• 81506-24-3 [3S-(1Z,3α,5β)]-2-[3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethanol 
• 81522-68-1 [(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide 
• 81506-25-4 <3S-(1Z,3α,5β)>-2-<3,5-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>-1-chloroethane 
• 127492-07-3 {2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl}-diphenyl-phosphane 
• 599165-21-6 3β-tert-butyldimethylsilyl-1α-tert-butyldimethylsilyloxy-25-trimethylsilyloxy-19-norvitamin D₃ 
• 60133-18-8 ercalcitriol 
• 32222-06-3 calcitriol 
• 227961-42-4 [3S-(1E,3α,5β)]-2-[3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethanol 

Relevant articles and documents

Enantioconvergent Preparation of the A-Ring Precursors of Calcitriol from Either (R)- or (S)-Epichlorohydrin

Linear and cyclic A-ring precursors of calcitriol have been prepared in both synthetically and enantiomerically convergent ways starting from either (R)- or (S)-epichlorohydrin.

Radical cyclization in heterocycle synthesis. 12. Sulfanyl radical addition-addition-cyclization (SRAAC) of unbranched diynes and its application to the synthesis of A-ring fragment of 1 α,25-dihydroxyvitamin d3

Sulfanyl radical addition-addition-cyclization (SRAAC) of unbranched diynes proceeded smoothly to give cyclized exo-olefins, while the sulfanyl radical addition-cyclization-addition (SRACA) of diynes having a quaternary carbon gave cyclized endo-olefins. This method was successfully applied to the synthesis of A-ring fragment of 1 α,25-dihydroxyvitamin D3.

Concise Enantiocontrolled Synthesis of the A-Ring Precursor of Calcitriol from the Chiral Cyclohexadienone Synthon

A new and concise enantiocontrolled route to the A-ring precursor of calcitriol is developed by utilizing the chiral cyclohexane-2,5-dienone synthon.