819056-67-2

Basic information

• Product Name: Urea, N-phenyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
• CAS NO: 819056-67-2
• Molecular Formula: C19H23BN2O3
• Molecular Weight: 338.214
• Mol File: 819056-67-2.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Urea, N-phenyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-phenyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-(819056-67-2)
• EPA Substance Registry System: Urea, N-phenyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-(819056-67-2)

Safety Data

• Hazardous Substances Data: 819056-67-2(Hazardous Substances Data)

Usage

General Description

The chemical urea, N-phenyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]- is a complex organic compound typically used as a reagent in chemical synthesis. It contains a urea group and a boron-containing aromatic ring, making it a versatile compound for various chemical reactions. The boron-containing moiety in this chemical can serve as a powerful Lewis acid catalyst, while the urea group can participate in hydrogen bonding interactions. This chemical has potential applications in organic synthesis, pharmaceutical research, and materials science due to its unique structural features and reactivity.

Upstream product

• 103-71-9 phenyl isocyanate 
• 106-40-1 4-bromo-aniline 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 13114-92-6 1-(4-bromophenyl)-3-phenyl-urea 
• 73183-34-3 bis(pinacol)diborane 
• 62-53-3 aniline 
• 2493-02-9 4-bromophenyl isocyanate 

Downstream Products

• 1219727-48-6 1-(4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-3-phenylurea 
• 959122-11-3 (1R,2R)-2-[[4'-[(phenylamino)carbonyl]amino][1,1'-biphenyl-4-yl]carbonyl]cyclopentanecarboxylic acid 
• 1075189-49-9 {[1-(5-{4-[(anilinocarbonyl)amino]phenyl}-4-methyl-1,3-thiazol-2-yl)cyclopentyl]oxy}acetic acid 
• 1075189-38-6 {[1-(5-{4-[(anilinocarbonyl)amino]phenyl}-1,3-thiazol-2-yl)cyclobutyl]oxy}acetic acid 

Relevant articles and documents

Having a spiro ring substituent of aryl morpholine compound, its preparation and use

The invention discloses arylmorpholine compounds with spiro substituents. The arylmorpholine compounds are compounds having the following general formula (I), wherein X is N or CH; R1 is hydrogen, hydroxyl, alkoxy, halogen, amino, amido, acylamino, sulfam

LIM KINASE INHIBITORS

A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For the human immunodeficiency virus (HIV), during viral entry, the virus triggers early actin activity through hijacking chemokine coreceptor signalin

Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors

The discovery/optimization of bis-aryl ureas as Limk inhibitors to obtain high potency and selectivity and appropriate pharmacokinetic properties through systematic SAR studies is reported. Docking studies supported the observed SAR. Optimized Limk inhibitors had high biochemical potency (IC50 400-fold), potent inhibition of cofilin phosphorylation in A7r5, PC-3, and CEM-SS T cells (IC50 1 μM), and good in vitro and in vivo pharmacokinetic properties. In the profiling against a panel of 61 kinases, compound 18b at 1 μM inhibited only Limk1 and STK16 with ≥80% inhibition. Compounds 18b and 18f were highly efficient in inhibiting cell-invasion/migration in PC-3 cells. In addition, compound 18w was demonstrated to be effective on reducing intraocular pressure (IOP) on rat eyes. Taken together, these data demonstrated that we had developed a novel class of bis-aryl urea derived potent and selective Limk inhibitors.