959122-11-3 Usage
Uses
A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.
Biological Activity
Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC 50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active.
Biochem/physiol Actions
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.
Check Digit Verification of cas no
The CAS Registry Mumber 959122-11-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,9,1,2 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 959122-11:
(8*9)+(7*5)+(6*9)+(5*1)+(4*2)+(3*2)+(2*1)+(1*1)=183
183 % 10 = 3
So 959122-11-3 is a valid CAS Registry Number.
959122-11-3Relevant articles and documents
Process development of a diacyl glycerolacyltransferase-1 inhibitor
Ravn, Matthew M.,Wagaw, Seble H.,Engstrom, Kenneth M.,Mei, Jianzhang,Kotecki, Brian,Souers, Andrew J.,Kym, Philip R.,Judd, Andrew S.,Zhao, Gang
, p. 417 - 424 (2011/04/22)
A synthesis of a selective diacyl glycerolacyltransferase-1 (DGAT-1) inhibitor, 1, is described. The synthesis illustrates a diketone Favorskii reaction on 9 in place of the more common ketoester variant for generation of the dicarboxycyclopentane core, t
