824430-39-9Relevant articles and documents
Synthesis and characterization of 3-aminoquinoline derivatives and studies of photophysicochemical behaviour and antimicrobial activities
Zengin, Gulay,Nafea Al Kawaz, Ali Muayad,Zengin, Huseyin,Mert, Adem,Kucuk, Bedia
, p. 45 - 55 (2016)
A series of 3-aminoquinoline derivatives were synthesized, where their chemical structures were confirmed by various analytical techniques, such as, Elemental Analysis, Nuclear Magnetic Resonance Spectroscopy (1H and 13C NMR), Liquid Chromatography-Mass-Mass Spectroscopy (LC-MS-MS), Ultraviolet-Visible Spectroscopy (UV-Vis), Fourier Transform Infrared Spectroscopy (FTIR) and Photoluminescence (PL). The quinoline ring core, typical of aminoquinolines, and a naphthalene group was combined to devise (4-alkyl-1-naphthyl)-quinolin-3-ylamide derivatives. These derivatives were designed and synthesized in light of the chemical and biological profiles of these important subunits. All the compounds were evaluated for their in vitro antibacterial and antifungal activities by the paper disc diffusion method with Gram-positive Bacillus subtilis, Bacillus megaterium and Staphylococcus aureus, Gram-negative Enterobacter aerogenes, Eschericha coli, Klebsiella pneumoniae and Pseudomonas aeruginosa and yeasts Candida albicans, Saccharomyces cerevisiae and Yarrovia lipolytica. These compounds showed antimicrobial activities against Gram-positive and Gram-negative bacteria and several yeasts, and thus their activity was not restricted to any particular type of microorganism.
Synthesis, evaluation of antimicrobial activity and theoretical analyses of novel sulfathiazole derivatives
Zengin, Gulay,Mert, Adem,Zengin, Huseyin
, p. 1 - 11 (2019/01/16)
Sulfathiazole derivatives (4-alkyl-1-naphthoylamino-N-thiazol-2-yl)benzenesulfonamides were synthesized, characterized by spectroscopic methods (FTIR, UV, NMR, PL), and tested for in vitro antimicrobial activity. These sulfathiazole derivatives were found to be more effective than the parent compound. According to the photoluminescence data, the compounds synthesized were found to give an intensive fluorescent blue light. Quantitative structure-activity relationship studies of these compounds and theoretical evaluations were carried out.
CB2-selective cannabinoid analogues
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Page 23, (2010/02/10)
Cannabinoid analogues that exhibit specificity for the CB2 cannabinoid receptor are provided. The analogues are 1-methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Δ8-tetrahydrocannabinols and 1-alkyl-3(1-naphthoyl)indoles. The compounds are useful for the treatment of pain (especially pain resulting from inflammation) and cancer (especially glioma tumors).