826-81-3Relevant articles and documents
Tassel, J. H. Van,Wendlandt, W. W.
, p. 4821 - 4823 (1960)
Nickel-Catalyzed Dehydrogenation of N-Heterocycles Using Molecular Oxygen
Banerjee, Debasis,Bera, Atanu,Bera, Sourajit
supporting information, (2020/09/02)
Herein, an efficient and selective nickel-catalyzed dehydrogenation of five- and six-membered N-heterocycles is presented. The transformation occurs in the presence of alkyl, alkoxy, chloro, free hydroxyl and primary amine, internal and terminal olefin, trifluoromethyl, and ester functional groups. Synthesis of an important ligand and the antimalarial drug quinine is demonstrated. Mechanistic studies revealed that the cyclic imine serves as the key intermediate for this stepwise transformation.
Method of preparing 8-hydroxy-2-methylquinoline by utilizing chlorquinaldol waste residues
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Paragraph 0026-0027; 0029-0030; 0032-0033; 0034-0036; 0038-0, (2018/09/11)
The invention belongs to the technical field of organic waste residue recovery and particularly relates to a method of preparing 8-hydroxy-2-methylquinoline by utilizing chlorquinaldol waste residues.The method comprises the following steps of in the presence of an acid binding agent, utilizing a hydrogenation catalyst to catalyze the chlorquinaldol waste residues, filtering the chlorquinaldol waste residues after catalytic hydrogenation, keeping a solid, performing dissolution with an acid liquid, regulating a pH value of a solution, then performing extraction, keeping an organic phase, andperforming drying and distillation to prepare the 8-hydroxy-2-methylquinoline. For the method provided by the invention, by using palladium-carbon hydroxide as the high-activity hydrogenation catalyst, deficiency of catalysts such as palladium on carbon, raney nickel and platinum on carbon to the reaction activity of a chlorinated product on a conjugate ring and harsh reaction conditions of high temperature, high pressure and the like are avoided, so that reaction is liable to control, the production period is short, and industrialization is liable.
Microwave-enhanced Friedl?nder synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria
Garrison, Aaron T.,Abouelhassan, Yasmeen,Yang, Hongfen,Yousaf, Hussain H.,Nguyen, Tho J.,Huigens, Robert W.III.
, p. 720 - 724 (2017/04/27)
Herein, we disclose the development of a catalyst- and protecting-group-free microwave-enhanced Friedl?nder synthesis which permits the single-step, convergent assembly of diverse 8-hydroxyquinolines with greatly improved reaction yields over traditional oil bath heating (increased from 34% to 72%). This rapid synthesis permitted the discovery of novel biofilm-eradicating halogenated quinolines (MBECs = 1.0-23.5 μM) active against MRSA, MRSE, and VRE. These small molecules exhibit activity through mechanisms independent of membrane lysis, further demonstrating their potential as a clinically useful treatment option against persistent biofilm-associated infections.