72-80-0Relevant articles and documents
Preparation method of chlorquinaldol
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Paragraph 0066-0093, (2021/10/27)
The invention provides a preparation method of chloroquinaldoll. The preparation method comprises the following step: in the presence of a catalyst Lewis acid, carrying out a reaction I on a material containing 8-hydroxy-2-methylquinoline and tert-butyl hypochlorite to obtain the chloroquinaldol. According to the method, the tert-butyl hypochlorite is used for replacing chlorine to serve as a reaction raw material, so good selectivity is achieved, byproducts are few, reaction operability is strong, light shielding and gas protection are not needed, quality and yield are improved, the purity of chlorquinaldol is 99.00% or more, and the quality of chlorquinaldol is ensured. In the reaction process, generation of waste liquid is reduced, pollution to the environment is avoided to the maximum extent, cost is saved, quality is improved, and the method is an environment-friendly process suitable for industrial production.
Preparation method of chloroquinaldol
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Paragraph 0034-0047, (2020/05/30)
The invention belongs to the technical field of medicines, and particularly relates to a preparation method of chloroquinaldol. The preparation method comprises the following steps: adding water intochloroquinaldol hydrochloride for dissolving, adding a buffer solution under the conditions of light shielding and nitrogen protection, regulating the pH value by using alkali, filtering and refiningthe solution to obtain chloroquinaldol. The method is easy and convenient to operate and suitable for industrial production, the purity of the prepared chloroquinaldol is high and can reach 99.99% orabove, and the stability of the product is high.
To 2 - methyl - 5, 7 - dichloro -8 - hydroxy quinoline as ligands of the single nucleus arrowhead complex and its preparation method and application
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Paragraph 0028; 0029, (2019/02/19)
The invention discloses a mononuclear dysprosium complex using 2-methyl-5,7-dichloro-8-hydroxyquinoline as a ligand and a preparation method and application thereof. A chemical formula of the complex is: [Dy(L)3(HL)], wherein L represents a product obtained after hydrogen atom of hydroxyl is removed from 2-methyl-5,7-dichloro-8-hydroxyquinoline, and has one unit of negative charges; HL represents 2-methyl-5,7-dichloro-8-hydroxyquinoline; the complex belongs to a triclinic system and a P-1 space group. The preparation method of the complex, which is disclosed by the invention, comprises: taking Dy(NO3)3.6H2O and 2-methyl-5,7-dichloro-8-hydroxyquinoline; dissolving Dy(NO3)3.6H2O and 2-methyl-5,7-dichloro-8-hydroxyquinoline with methanol; regulating pH of the obtained solution into a range of 6.5 to 7.8; performing a reaction on the obtained mixed solution under the heating condition to obtain the mononuclear dysprosium complex. The complex provided by the invention is simple in preparation method, low in cost and good in repeatability, shows a field-induced slow relaxation magnetic behavior at a low temperature, and can be used for preparing a magnetic material.