82657-72-5 Usage
Description
1-(BROMOMETHYL)-2-PHENOXYBENZENE is an organic compound that features a bromomethyl group attached to a benzene ring, with a phenoxy group attached to the adjacent carbon. This unique structure allows it to be utilized in various chemical reactions and applications, particularly in the field of medicinal chemistry and materials science.
Uses
Used in Pharmaceutical and Medicinal Chemistry:
1-(BROMOMETHYL)-2-PHENOXYBENZENE is used as a key intermediate in the synthesis of various pharmaceutical compounds and drug candidates. Its bromomethyl group can be used for further functionalization, allowing the creation of new molecules with potential therapeutic properties.
Used in the Preparation of CRAC Channels:
1-(BROMOMETHYL)-2-PHENOXYBENZENE is used in the preparation of CRAC (Ca2+ release-activated Ca2+) channels using photoswitchable azopyrazoles. These channels play a crucial role in cellular calcium signaling, and their modulation can have significant implications in various physiological processes and potential therapeutic applications.
Used in Materials Science:
1-(BROMOMETHYL)-2-PHENOXYBENZENE can be employed in the development of new materials with specific properties, such as photoresponsive materials or materials with tailored chemical reactivity. Its ability to undergo various chemical reactions makes it a versatile building block for the design of advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 82657-72-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,6,5 and 7 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 82657-72:
(7*8)+(6*2)+(5*6)+(4*5)+(3*7)+(2*7)+(1*2)=155
155 % 10 = 5
So 82657-72-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H11BrO/c14-10-11-6-4-5-9-13(11)15-12-7-2-1-3-8-12/h1-9H,10H2
82657-72-5Relevant articles and documents
Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles
Yang, Xingye,Ma, Guolin,Zheng, Sisi,Qin, Xiaojun,Li, Xiang,Du, Lupei,Wang, Youjun,Zhou, Yubin,Li, Minyong
, p. 9460 - 9470 (2020/06/27)
The Ca2+ release-activated Ca2+ (CRAC) channels control many Ca2+-modulated physiological processes in mammals. Hyperactivating CRAC channels are known to cause several human diseases, including Stormorken syndrome. Here, we show the design of azopyrazole-derived photoswitchable CRAC channel inhibitors (designated piCRACs), which enable optical inhibition of store-operated Ca2+ influx and downstream signaling. Moreover, piCRAC-1 has been applied in vivo to alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.
AMINOPEPTIDASE A INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
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, (2020/06/10)
The present invention relates to a novel compound, to a composition comprising the same, to methods for preparing the compound, and the use of this compound in therapy. In particular, the present invention relates to compound that is useful in the treatment and prevention of primary and secondary arterial hypertension, ictus, myocardial ischaemia, cardiac and renal insufficiency, myocardial infarction, peripheral vascular disease, diabetic proteinuria, Syndrome X and glaucoma.
Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof
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Page/Page column 49, (2011/04/14)
The invention relates to compounds of formula (I) wherein the groups R and R′ A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.
