83140-94-7

Basic information

• Product Name: [3-(1H-PYRROL-1-YL)PHENYL]METHANOL
• Synonyms: RARECHEM AL BD 1294;BUTTPARK 96\50-03;[3-(1H-PYRROL-1-YL)PHENYL]METHANOL
• CAS NO: 83140-94-7
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.21
• Mol File: 83140-94-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 70 °C
• Boiling Point: 334.7°C at 760 mmHg
• Flash Point: 156.2°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 4.97E-05mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: [3-(1H-PYRROL-1-YL)PHENYL]METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(1H-PYRROL-1-YL)PHENYL]METHANOL(83140-94-7)
• EPA Substance Registry System: [3-(1H-PYRROL-1-YL)PHENYL]METHANOL(83140-94-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 83140-94-7(Hazardous Substances Data)

Usage

General Description

[3-(1H-PYRROL-1-YL)PHENYL]METHANOL, also known as 1-(3-hydroxyphenyl)pyrrole, is a chemical compound with the molecular formula C11H11NO. It is a derivative of phenethylamine and contains a phenyl group substituted with a pyrrole ring and a hydroxyl group. [3-(1H-PYRROL-1-YL)PHENYL]METHANOL has applications in organic synthesis and medicinal chemistry, where it can be used as a building block for the synthesis of various pharmaceuticals and biologically active compounds. It may also have potential therapeutic applications due to its structural resemblance to other bioactive molecules. Additionally, it can be used as a reagent in chemical reactions to introduce the pyrrole and phenyl rings into other molecules.

InChI:InChI=1/C11H11NO/c13-9-10-4-3-5-11(8-10)12-6-1-2-7-12/h1-8,13H,9H2

Upstream product

• 83140-93-6 methyl 3-(1H-pyrrol-1-yl)benzoate 
• 4518-10-9 Methyl 3-aminobenzoate 
• 83140-93-6 ethyl 3-(pyrrol-1-yl)benzoate 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 1877-77-6 3-aminobenzenemethanol 

Downstream Products

• 112596-36-8 1-[3-(bromomethyl)phenyl]-1H-pyrrole 
• 112575-86-7 3-pyrrol-1-ylbenzeneethanenitrile 
• 112575-87-8 3-pyrrol-1-ylphenylacetic acid 
• 112575-85-6 methyl 3-pyrrol-1-ylphenylacetate 
• 112596-35-7 (3-Pyrrol-1-yl-phenyl)-acetic acid hydrazide 
• 1202576-73-5 (6A) Ethyl 3-ethoxy-3-(4-{[3-(1H-pyrrol-1-yl)benzyl]oxy}phenyl)propionate 

Relevant articles and documents

Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

The free fatty acid receptor 1 (FFA1) has gained significant interest as a novel antidiabetic target. Most of FFA1 agonists reported in the literature bearing a common biphenyl scaffold, which was crucial for toxicity verified by the researchers of Daiichi Sankyo. Herein, we describe the systematic exploration of non-biphenyl scaffold and further chemical modification of the optimal pyrrole scaffold. All of these efforts led to the identification of compound 11 as a potent and orally bioavailable FFA1 agonist without the risk of hypoglycemia. Further molecular modeling studies promoted the understanding of ligand-binding pocket and might help to design more promising FFA1 agonists.

Substituted alkylamine derivatives

The substituted alkylamine derivatives represented by formula (I) STR1 wherein R1 represents (a) substituted or unsubstituted C2-6 alkenyl group, (b) substituted or unsubstituted C3-6 cycloalkenyl group, (c) substituted or unsubstituted C2-6 alkynyl group, (d) substituted or unsubstituted aryl group, (e) substituted or unsubstituted heterocyclic group, (f) fused heterocyclic group which may be substituted, or (g) group represented by the formula Ru11 -Ar wherein R11 is a heterocyclic group and Ar is a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and which may be substituted; STR2 represents a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and may be substituted by R7, X and Y are linking groups, R2 is H or lower alkyl, R3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl, R4 and R5 are independently hydrogen or halogen atoms, R6 represents (a) substituted or unsubstituted acyclic hydrocarbon group which may be unsaturated, (b) substituted or unsubstituted cycloalkyl group, or (c) substituted or unsubstituted phenyl group, or non-toxic salts thereof. (E)-N-(6-6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-[4-(3-thienyl)-2-thienyl-methyloxy]benzylamine hydrochloride is a representative example. The substituted alkylamine derivatives are useful as pharmaceuticals, particularly for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.

3-(Pyrrol-1-yl)phenylmethyl esters and intermediates

3-(Pyrrol-1-yl)phenylmethyl esters and intermediates having the general formula STR1 the use of the esters as pesticides, compositions thereof and a process for preparation are disclosed and exemplified.