841296-15-9

Basic information

• Product Name: 4-Amino-3-formyl-benzoic acid methyl ester
• Synonyms: 4-Amino-3-formyl-benzoic acid methyl ester;Methyl 4-aMino-3-forMylbenzoate
• CAS NO: 841296-15-9
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.18
• Product Categories: Pharmaceutical intermediate
• Mol File: 841296-15-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 122-124 °C
• Boiling Point: 374.203 °C at 760 mmHg
• Flash Point: 216.807 °C
• Appearance: /
• Density: 1.268 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -1.77±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-3-formyl-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-formyl-benzoic acid methyl ester(841296-15-9)
• EPA Substance Registry System: 4-Amino-3-formyl-benzoic acid methyl ester(841296-15-9)

Safety Data

• Hazardous Substances Data: 841296-15-9(Hazardous Substances Data)

Usage

General Description

4-Amino-3-formyl-benzoic acid methyl ester, also known as Methyl 4-amino-3-formylbenzoate, is a chemical compound with the molecular formula C9H9NO3. It is an ester formed from the condensation of 4-Amino-3-formylbenzoic acid and methanol. 4-Amino-3-formyl-benzoic acid methyl ester is commonly used in organic synthesis as an intermediate in the production of pharmaceuticals and agrochemicals. It has been studied for its potential applications in drug discovery and organic reactions. Additionally, its molecular structure and properties make it a valuable building block in the synthesis of complex organic compounds.

Upstream product

• 841296-14-8 4-amino-3-dimethoxymethyl-benzoic acid methyl ester 
• 148625-35-8 methyl 3-formyl-4-nitrobenzoate 

Downstream Products

• 841296-42-2 2-[4'-chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carboxylic acid 
• 841296-38-6 2-[2-hydroxy-5-(pyrrolidine-1-carbonyl)-phenyl]-quinoline-6-carboxylic acid 
• 1315578-07-4 methyl 2-phenylquinazoline-6-carboxylate 
• 1315578-13-2 methyl 2-p-tolylquinazoline-6-carboxylate 
• 1395473-89-8 (S)-methyl 2-(4-methoxyphenyl)-1,2,3,4-tetrahydroquinoline-6-carboxylate 
• 1036755-96-0 methyl 2-chloroquinazoline-6-carboxylate 

Relevant articles and documents

INHIBITORS OF ENL/AF9 YEATS

Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.

Gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amines: An expedient route to 3-aminoquinolines

Access to aminoquinolines: A gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amine was studied. The study provided, for the first time, direct access to 3-aminoquinolines in one step starting from readily available starting materials (see scheme). Elegantly designed experiments were employed to unravel the mechanism of this unprecedented rearrangement, which are corroborated by DFT calculations.

α-amination of nitrogen heterocycles: Ring-fused aminals

Aromatic aminoaldehydes react with cyclic amines to produce ring-fused aminals under thermal conditions. This process is applied to two-step syntheses of the quinazolinone alkaloids deoxyvasicinone and rutaecarpine. Copyright