846023-57-2Relevant articles and documents
Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles
Boschelli, Diane H.,Wu, Biqi,Ye, Fei,Wang, Yan,Golas, Jennifer M.,Lucas, Judy,Boschelli, Frank
, p. 7868 - 7876 (2006)
Compound 1 (SKI-606, bosutinib), a 7-alkoxy-4-[(2,4-dichloro-5- methoxyphenyl)amino]-3-quinolinecarbonitrile, is a potent inhibitor of Src kinase activity. We previously reported that analogs of 1 with thiophene groups at C-7 retained the Src activity of