846023-62-9

Basic information

• Product Name: (2E/Z)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-[(4-methoxy-3-{5-[(4-methyl-1-piperazinyl)methyl]-3-furanyl}phenyl)amino]-2-propenamide
• Synonyms: (2E/Z)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-[(4-methoxy-3-{5-[(4-methyl-1-piperazinyl)methyl]-3-furanyl}phenyl)amino]-2-propenamide
• CAS NO: 846023-62-9
• Molecular Weight: 570.475
• Mol File: 846023-62-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2E/Z)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-[(4-methoxy-3-{5-[(4-methyl-1-piperazinyl)methyl]-3-furanyl}phenyl)amino]-2-propenamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E/Z)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-[(4-methoxy-3-{5-[(4-methyl-1-piperazinyl)methyl]-3-furanyl}phenyl)amino]-2-propenamide(846023-62-9)
• EPA Substance Registry System: (2E/Z)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-[(4-methoxy-3-{5-[(4-methyl-1-piperazinyl)methyl]-3-furanyl}phenyl)amino]-2-propenamide(846023-62-9)

Safety Data

• Hazardous Substances Data: 846023-62-9(Hazardous Substances Data)

Upstream product

• 98446-49-2 2,4-dichloro-5-methoxyaniline 
• 5399-03-1 2-iodo-1-methoxy-4-nitrobenzene 
• 846023-24-3 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide 
• 846023-60-7 (4-methoxy-3-{5-[(4-methylpiperazin-1-yl)methyl]-3-furyl}-phenyl)amine 
• 122-51-0 orthoformic acid triethyl ester 
• 21921-76-6 4-bromo-2-furancarbaldehyde 
• 109-01-3 1-methyl-piperazine 
• 846023-59-4 1-{[4-(2-methoxy-5-nitrophenyl)-2-furyl]methyl}-4-methylpiperazine 
• 846023-57-2 4-(2-methoxy-5-nitrophenyl)-2-furaldehyde 
• 846023-61-8 1-[(4-bromo-2-furyl)methyl]-4-methylpiperazine 
• 846023-58-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-furancarboxaldehyde 

Relevant articles and documents

Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles

Compound 1 (SKI-606, bosutinib), a 7-alkoxy-4-[(2,4-dichloro-5- methoxyphenyl)amino]-3-quinolinecarbonitrile, is a potent inhibitor of Src kinase activity. We previously reported that analogs of 1 with thiophene groups at C-7 retained the Src activity of