846541-71-7 Usage
General Description
5-Chloro-4,6-dihydroxynicotinic acid ethyl ester is a chemical compound that belongs to the class of organic compounds known as pyridine carboxylic acids. It is derived from nicotinic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is known for its diverse applications, including its use as a building block in the production of various drugs and pesticides. Its properties and structure make it an important component for the development of new compounds with potential therapeutic and agricultural benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 846541-71-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,6,5,4 and 1 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 846541-71:
(8*8)+(7*4)+(6*6)+(5*5)+(4*4)+(3*1)+(2*7)+(1*1)=187
187 % 10 = 7
So 846541-71-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H8ClNO4/c1-2-14-8(13)4-3-10-7(12)5(9)6(4)11/h3H,2H2,1H3,(H2,10,11,12)
846541-71-7Relevant articles and documents
Potent and selective mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors. 1. 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1h)-ones
Wallace, Eli M.,Lyssikatos, Joseph,Blake, James F.,Seo, Jeongbeob,Yang, Hong Woon,Yeh, Tammie C.,Perrier, Michele,Jarski, Heidi,Marsh, Vivienne,Poch, Gregory,Livingston, Michelle Goyette,Otten, Jennifer,Hingorani, Gary,Woessner, Rich,Lee, Patrice,Winkler, James,Koch, Kevin
, p. 441 - 444 (2007/10/03)
The role of MEK 1,2 in cancer tumorgenesis has been clearly demonstrated preclinically, and two selective inhibitors are currently undergoing clinical evaluation to determine their role in the human disease. We have discovered 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1H)-ones as a new class of ATP noncompetitive MEK inhibitors. These inhibitors exhibit excellent cellular potency and good pharmacokinetic properties and have demonstrated the ability to inhibit ERK phosphorylation in HT-29 tumors from mouse xenograft studies.