874353-12-5

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 4-[(4-bromo-2-chlorophenyl)amino]-5-chloro-6-methoxy-
• CAS NO: 874353-12-5
• Molecular Formula: C13H9BrCl2N2O3
• Molecular Weight: 392.036
• Mol File: 874353-12-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 4-[(4-bromo-2-chlorophenyl)amino]-5-chloro-6-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 4-[(4-bromo-2-chlorophenyl)amino]-5-chloro-6-methoxy-(874353-12-5)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 4-[(4-bromo-2-chlorophenyl)amino]-5-chloro-6-methoxy-(874353-12-5)

Safety Data

• Hazardous Substances Data: 874353-12-5(Hazardous Substances Data)

Upstream product

• 846541-71-7 ethyl 5-chloro-4,6-dihydroxynicotinate 
• 181261-73-4 ethyl 4,5,6-trichloronicotinate 
• 6975-44-6 4,6-dihydroxynicotinic acid ethyl ester 
• 847373-08-4 4-(4-bromo-2-chlorophenylamino)-5,6-dichloronicotinic acid 
• 847373-09-5 methyl 4-(4-bromo-2-chlorophenylamino)-5,6-dichloronicotinate 
• 847608-28-0 4,5,6-trichloronicotinic acid 
• 874353-11-4 methyl 4-(4-bromo-2-chlorophenylamino)-5-chloro-6-methoxynicotinate 

Relevant articles and documents

Potent and selective mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors. 1. 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1h)-ones

The role of MEK 1,2 in cancer tumorgenesis has been clearly demonstrated preclinically, and two selective inhibitors are currently undergoing clinical evaluation to determine their role in the human disease. We have discovered 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1H)-ones as a new class of ATP noncompetitive MEK inhibitors. These inhibitors exhibit excellent cellular potency and good pharmacokinetic properties and have demonstrated the ability to inhibit ERK phosphorylation in HT-29 tumors from mouse xenograft studies.