84832-00-8

Basic information

• Product Name: 5-AMINO-2-FLUOROBENZYL ALCOHOL
• Synonyms: 5-AMINO-2-FLUOROBENZYL ALCOHOL;(5-AMINO-2-FLUORO-PHENYL)-METHANOL;5-Amino-2-fluorobenzyl alcohol 99%;(5-Amino-2-fluorophenyl)methanol, 4-Fluoro-3-(hydroxymethyl)aniline;5-Amino-2-fluorobenzylalcohol99%;(5-Amino-2-fluorophenyl)
• CAS NO: 84832-00-8
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.14
• Product Categories: pharmacetical
• Mol File: 84832-00-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 99-100°
• Boiling Point: 295.4°C at 760 mmHg
• Flash Point: 132.5°C
• Appearance: /
• Density: 1.286g/cm³
• Vapor Pressure: 0.000691mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.05±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-2-FLUOROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-FLUOROBENZYL ALCOHOL(84832-00-8)
• EPA Substance Registry System: 5-AMINO-2-FLUOROBENZYL ALCOHOL(84832-00-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 84832-00-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 327, 1990 DOI: 10.1021/jm00163a053

InChI:InChI=1/C7H8FNO/c8-7-2-1-6(9)3-5(7)4-10/h1-3,10H,4,9H2

Upstream product

• 56741-34-5 methyl 5-amino-2-fluorobenzoate 
• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 56741-33-4 5-amino-2-fluorobenzoic acid 
• 27996-87-8 2-fluoro-5-nitrobenzaldehye 

Downstream Products

• 123207-52-3 N-<4-fluoro-3-(hydroxymethyl)phenyl>-2-pyridinecarboxamide 
• 123207-53-4 Pyridine-2-carboxylic acid 2-fluoro-5-[(pyridine-2-carbonyl)-amino]-benzyl ester 
• 84832-04-2 2-[(4-Fluoro-3-hydroxymethyl-phenylamino)-methylene]-malonic acid diethyl ester 
• 84832-06-4 diethyl 2-(3-acetoxymethyl-4-fluoroanilino)methylenemalonate 
• 123207-54-5 N-<3-bromomethyl)-4-fluorophenyl>-2-pyridinecarboxamide 
• 123207-58-9 N-<4-fluoro-3-(1H-imidazol-1-ylmethyl)phenyl>-2-pyridinecarboxamide 
• 123207-50-1 N-<4-fluoro-3-(1H-imidazol-1-ylmethyl)phenyl>-2-pyridinecarbothioamide 
• 123207-59-0 N-<4-fluoro-3-(piperidinylmethyl)phenyl>-2-pyridinecarboxamide 
• 123207-60-3 N-<4-fluoro-3-(piperidinylmethyl)phenyl>-2-pyridinecarbothioamide 
• 642085-13-0 tert-butyl N-[4-fluoro-3-(hydroxymethyl)phenyl]carbamate 
• 1138813-99-6 C₇H₉FN₂O 
• 1296309-49-3 (2-fluoro-5-morpholinophenyl)methanol 
• 1569736-82-8 3-[(cyclopentylsulfanyl)methyl]-4-fluoroaniline 
• 1569737-02-5 N-{3-[(cyclopentylsulfanyl)methyl]-4-fluorophenyl}thiophene-2-carboximidamide 

Relevant articles and documents

Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE)

Hereditary angioedema (HAE) is a rare and potentially life-threatening disease that affects an estimated 1 in 50000 individuals worldwide. Until recently, prophylactic HAE treatment options were limited to injectables, a burdensome administration route that has driven the need for an oral treatment. A substantial body of evidence has shown that potent and selective plasma kallikrein inhibitors that block the generation of bradykinin represent a promising approach for the treatment of HAE. Berotralstat (BCX7353, discovered by BioCryst Pharmaceuticals using a structure-guided drug design strategy) is a synthetic plasma kallikrein inhibitor that is potent and highly selective over other structurally related serine proteases. This once-daily, small-molecule drug is the first orally bioavailable prophylactic treatment for HAE attacks, having successfully completed a Phase III clinical trial (meeting its primary end point) and recently receiving the U.S. Food and Drug Administration's approval for the prophylactic treatment of HAE attacks in patients 12 years and older.

Studies on biologically active halogenated compounds. IV. synthesis and antibacterial activity of fluorinated quinoline derivatives

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