85-06-3

Basic information

• Product Name: 3-METHYLBENZO-5,6-QUINOLINE
• Synonyms: 3-METHYLBENZO-5,6-QUINOLINE;5,6-BENZOQUINALDINE;B-NAPHTHOQUINALDINE;3-Methylbenzo[f]quinoline;beta-Naphthoquinaldine;2-methyl-5,6-benzoquinoline;-Naphthochinaldin
• CAS NO: 85-06-3
• Molecular Formula: C₁₄H₁₁N
• Molecular Weight: 193.24
• EINECS: 201-584-1
• Mol File: 85-06-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 73-78°C
• Boiling Point: 352.5 °C at 760 mmHg
• Flash Point: 154.8 °C
• Appearance: /
• Density: 1.155
• Vapor Pressure: 7.75E-05mmHg at 25°C
• Refractive Index: 1.703
• Storage Temp.: 2-8°C
• PKA: 5.92±0.40(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-METHYLBENZO-5,6-QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLBENZO-5,6-QUINOLINE(85-06-3)
• EPA Substance Registry System: 3-METHYLBENZO-5,6-QUINOLINE(85-06-3)

Safety Data

• Safety Statements: 22-24/25
• TSCA: Yes
• Hazardous Substances Data: 85-06-3(Hazardous Substances Data)

Usage

General Description

3-METHYLBENZO-5,6-QUINOLINE is a chemical compound with the molecular formula C15H11N. It is a heterocyclic aromatic compound with a quinoline core and a methyl group attached to the benzene ring. 3-METHYLBENZO-5,6-QUINOLINE is used in the synthesis of pharmaceuticals and agrochemicals due to its biological activities and potential therapeutic uses. It is also used as a ligand in the coordination chemistry of transition metal complexes. Additionally, 3-METHYLBENZO-5,6-QUINOLINE has been studied for its potential antitumor and antimicrobial properties, making it a subject of interest in medicinal chemistry research.

InChI:InChI=1/C14H11N/c1-10-6-8-13-12-5-3-2-4-11(12)7-9-14(13)15-10/h2-9H,1H3

Upstream product

• 123-73-9 trans-Crotonaldehyde 
• 91-59-8 naphthalen-2-ylamine 
• 612-52-2 2-naphthylamine hydrochloride 
• 581-97-5 2-acetylaminonaphthalene 
• 13259-29-5 sodium isobutoxide 
• 123-63-7 paracetaldehyde 
• 85-02-9 benzo[f]quinoline 
• 917-54-4 methyllithium 
• 1136-25-0 3-methyl-1,2,3,4-tetrahydrobenzo[f]quinoline 
• 64-17-5 ethanol 
• 17104-69-7 5,6-benzoquinoline N-oxide 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 2181-42-2 trimethylsulphonium iodide 
• 872-36-6 vinylene carbonate 

Downstream Products

• 59066-59-0 3-[(E)-2-phenylethenyl]benzo[f]quinoline 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 117638-90-1 C₂₁H₁₇N₅ 
• 103035-56-9 3-benzo[f]quinolin-3-yl-N-(2-carboxy-phenyl)-N'''-phenyl-formazan 
• 1308280-30-9 3-(E)-(4-hydroxystyryl)benzo[f]quinoline 
• 1422009-71-9 3-(benzo[f]quinolin-3-ylmethyl)-1-phenylpyrrolidine-2,5-dione 
• 18125-24-1 benzo[f]quinoline-3-carbonitrile 

Relevant articles and documents

Rhodium-Catalyzed C-H Annulation of Free Anilines with Vinylene Carbonate as a Bifunctional Synthon

Chemical transformation with vinylene carbonate as an emerging synthetic unit has recently attracted considerable attention. This report is a novel conversion pattern with vinylene carbonate, in which such a vibrant reagent unprecedentedly acts as a difunctional coupling partner to complete the C-H annulation of free anilines. From commercially available substrates, this protocol leads to the rapid construction of synthetically versatile 2-methylquinoline derivatives (43 examples) with excellent functionality tolerance.

A ortho position alkylation method of organic compound containg pyridine

A process for introducing alkyl at ortho positions of organic compounds containing pyridine. The method is not affected by the kind of substituent bonded to the pyridine and can be alkylated with high positional selectivity and high yield at N-based ortho-position of pyridine without being affected by the kind of substituent introduced to pyridine ortho position (pyridine N-based) can be advantageously used for the preparation of a compound containing an alkyl-introduced pyridine structure.

Organo-Photoredox Catalyzed Oxidative Dehydrogenation of N-Heterocycles

We report here for the first time the catalytic oxidative dehydrogenation of N-heterocycles by a visible-light organo-photoredox catalyst with low catalyst loading (0.1–1 mol %). The reaction proceeds efficiently under base- and additive-free conditions with ambient air at room temperature. The utility of this benign approach is demonstrated by the synthesis of various pharmaceutically relevant N-heteroarenes such as quinoline, quinoxaline, quinazoline, acridine, and indole.