85-38-1Relevant articles and documents
Continuous flow nitration of salicylic acid
Kulkarni, Amol A.,Nivangune, Nayana T.,Kalyani, Vishwanath S.,Joshi, Ramesh A.,Joshi, Rohini R.
, p. 995 - 1000 (2008)
Continuous flow nitration of salicylic acid using HNO3/AcOH was studied in the SS316 tubular microreactor. At specific reaction conditions, complete conversion of the reactant was achieved in less than 7 min. It yielded only mononitro derivatives with a higher selectivity of 5-nitrosalicylic acid. Presence of the lower amount of acetic acid in the reaction mixture was seen to be detrimental, leading to precipitation of the desired product (5-nitrosalicylic acid). Reaction at higher temperatures yielded byproducts. The continuous mode operation using the system comprising the microdevices was demonstrated for 2 h with consistent composition at the outlet
Method for selectively synthesizing 3-nitrosalicylic acid in continuous flow region
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Paragraph 0047-0087, (2021/03/24)
The invention provides a method for selectively synthesizing 3-nitrosalicylic acid in a continuous flow region. According to the method, salicylic acid and nitric acid are used as raw materials and react in a micro-channel reactor in the presence of a cat
Improved synthesis of 3-nitrosalicylic acid
Hummel, Michael,Laus, Gerhard,Nerdinger, Sven,Schottenberger, Herwig
experimental part, p. 3353 - 3357 (2010/12/24)
Nitration of salicylic acid using 2-propyl nitrate/sulfuric acid/tetrabutylammonium hydrogensulfate/dichloromethane/water yielded a mixture of 3-nitro and 5-nitrosalicylic acids in the ratio 56:44. Pure potassium 3-nitrosalicylate was crystallized and converted to 3-nitrosalicylic acid in 30% overall yield. Copyright