851178-98-8 Usage
General Description
3-Chloro-4,5-difluoropyridine is a chemical compound with the molecular formula C5H2ClF2N. It is a member of the pyridine family, which is a type of aromatic heterocyclic compound. This particular chemical is characterized by the presence of a chlorine atom and two fluorine atoms attached to the pyridine ring. It is commonly used as a building block in organic synthesis, particularly in the pharmaceutical industry where it can be utilized in the production of various drugs and pharmaceutical products. Due to its unique chemical structure, 3-Chloro-4,5-difluoropyridine exhibits specific reactivity and can participate in a variety of chemical reactions, making it a valuable intermediate in the synthesis of complex organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 851178-98-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,1,7 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 851178-98:
(8*8)+(7*5)+(6*1)+(5*1)+(4*7)+(3*8)+(2*9)+(1*8)=188
188 % 10 = 8
So 851178-98-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H2ClF2N/c6-3-1-9-2-4(7)5(3)8/h1-2H
851178-98-8Relevant articles and documents
Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution
Bobbio, Carla,Rausis, Thierry,Schlosser, Manfred
, p. 1903 - 1910 (2007/10/03)
Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.