514797-99-0

Basic information

• Product Name: 3-Chloro-5-fluoropyridine
• Synonyms: 3-CHLORO-5-FLUOROPYRIDINE;3-Fluoro-5-chloropyridine;Pyridine, 3-chloro-5-fluoro- (9CI)
• CAS NO: 514797-99-0
• Molecular Formula: C₅H₃ClFN
• Molecular Weight: 131.54
• Product Categories: PYRIDINE;HALIDE;Halides;Heterocycles;Fluorine series
• Mol File: 514797-99-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 25-27℃
• Boiling Point: 134°C(lit.)
• Flash Point: 41°(106°F)
• Appearance: /
• Density: 1.331
• Refractive Index: 1.503
• Storage Temp.: Room temperature.
• PKA: 0.52±0.20(Predicted)
• CAS DataBase Reference: 3-Chloro-5-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-5-fluoropyridine(514797-99-0)
• EPA Substance Registry System: 3-Chloro-5-fluoropyridine(514797-99-0)

Safety Data

• Hazard Codes: T,Xi,Xn,F
• Statements: 11-22-37/38-41
• Safety Statements: 26-39
• RIDADR: UN1325 - class 4.1 - PG 3 - Flammable solids, organic, n.o.s., H
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: II
• Hazardous Substances Data: 514797-99-0(Hazardous Substances Data)

Usage

General Description

3-Chloro-5-fluoropyridine is a heterocyclic organic compound with the molecular formula C5H3ClFN. It is classified as a chloropyridine derivative and contains a pyridine ring with chlorine and fluorine substituents. The compound is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It can also be used in the production of dyes, pigments, and other specialty chemicals. 3-Chloro-5-fluoropyridine is a colorless to pale yellow liquid with a sharp, pungent odor and is considered to be mildly toxic. It is important to handle and store this chemical with care, following proper safety protocols and regulations.

InChI:InChI=1/C5H3ClFN/c6-4-1-5(7)3-8-2-4/h1-3H

Upstream product

• 514797-97-8 2-bromo-5-chloro-3-fluoro-pyridine 
• 248255-70-1 5-chloro-3-fluoro-2-hydrazinylpyridine 
• 89402-43-7 5-chloro-2,3-difluoropyridine 
• 514797-96-7 5-chloro-3-fluoro-2(1H)-pyridinone 
• 514798-05-1 2-bromo-5-chloro-3-fluoro-4-iodopyridine 
• 2457-47-8 3,5-dichloropyridine 

Downstream Products

• 514798-03-9 3-chloro-5-fluoro-4-pyridinecarboxylic acid 
• 514798-07-3 3-chloro-5-fluoro-4-iodo-pyridine 
• 851179-02-7 3,4-dichloro-5-fluoropyridine 
• 82878-63-5 3,4-difluoropyridine 
• 851178-98-8 3-chloro-4,5-difluoropyridine 
• 372-47-4 3-Fluoropyridine 
• 2546-56-7 4-chloro-3-fluoro-pyridine 
• 1341636-88-1 4-trans(5-chloro-pyridin-3-yloxy)cyclohexylamine 
• 2200-71-7 2,2',3,3',5,5',6,6'-octafluoro-4,4'-dimethoxy-1,1'-biphenyl 
• 1322575-18-7 3-chloro-5-fluoro-4-(2,3,5,6-tetrafluoro-4-methoxyphenyl)pyridine 
• 1431307-96-8 ethyl 4-(3-chloro-5-fluoropyridin-4-yl)benzoate 

Relevant articles and documents

PROCESS FOR FLUORINATING COMPOUNDS

Methods of preparing a fluorinated aryl or heteroaryl substrate by combining a quaternary ammonium cyanide and an aryl or heteroaryl substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide a mixture, and combining the mixture with hexafluorobenzene to thereby provide the fluorinated substrate.

Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution

Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.