85118-00-9Relevant articles and documents
Hydrogen Bond Directed Photocatalytic Hydrodefluorination and Methods of Use Thereof
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Paragraph 0182, (2021/01/22)
Methods of synthesizing compounds comprising fluorinated aryl groups are disclosed, wherein said methods utilize hydrogen bond directed photocatalytic hydrodefluorination.
[4,5]-fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia
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, (2008/06/13)
[4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: wherein Y1and Y2are independently selected from the group consisting of (CH2)n,—C(X)—NH—,—(CH2)n—C(X)—O—, and X is O or S; R1is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, and substituted or unsubstituted phenyl, pyridinyl, and the like; R2is selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyridinyl, and the like; “A” is a benzene ring fused with the pyridazine ring; and R3is independently selected in each instance form the group consisting of halogen, lower alkyl, and the like.
Fluorine Magnetic Resonance Studies. VI. Fluorine-Fluorine Coupling Over Four Bonds in α-Fluoro- and α,α-Difluoro-toluenes
Rae, Ian D.,Burgess, David A.,Bombaci, Sebastian,Baron, Margaret L.,Woolcock, Mark L.
, p. 1437 - 1446 (2007/10/02)
The 4J fluorine-fluorine coupling over four bonds involving an sp3 carbon and two sp2 carbons has been studied by using constrained structures to calibrate the dependence of the size of coupling on the dihedral angle (θ).Both CF and CF2 groups follow the pattern established for CF3, with the largest couplings (38, 62 and 86 Hz respectively) arising from closest approaches of two fluorines (θ = 0 deg) and the zero couplings resulting from θ = 180 deg.
