85329-86-8 Usage
Description
Desethylcarbamoyl Cabergoline is a metabolite of Cabergoline, a drug that has affinity for D1 and D2 dopamine receptors in rat striatum. It is characterized by its tan solid chemical properties.
Uses
Used in Pharmaceutical Industry:
Desethylcarbamoyl Cabergoline is used as a pharmaceutical intermediate for the synthesis of Cabergoline, a drug that modulates dopamine receptors and is used in the treatment of various conditions such as Parkinson's disease and hyperprolactinemia.
Used in Research Applications:
Desethylcarbamoyl Cabergoline is used as a research tool for studying the role of D1 and D2 dopamine receptors in the rat striatum. It helps researchers understand the mechanisms of action and potential therapeutic applications of Cabergoline and other dopamine receptor modulators.
Check Digit Verification of cas no
The CAS Registry Mumber 85329-86-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,3,2 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 85329-86:
(7*8)+(6*5)+(5*3)+(4*2)+(3*9)+(2*8)+(1*6)=158
158 % 10 = 8
So 85329-86-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H32N4O/c1-4-10-27-15-17(23(28)24-9-6-11-26(2)3)12-19-18-7-5-8-20-22(18)16(14-25-20)13-21(19)27/h4-5,7-8,14,17,19,21,25H,1,6,9-13,15H2,2-3H3,(H,24,28)/t17-,19?,21-/m1/s1
85329-86-8Relevant articles and documents
Synthesis of European pharmacopoeial impurities A, B, C, and D of cabergoline
Wagger, Jernej,Pozes, Aljaz,Pozgan, Franc
, p. 23146 - 23156 (2013/11/19)
For the use of analytics, European pharmacopoeial impurities A, B, C, and D of cabergoline were synthesized. Ergocryptine was chosen as a starting material and synthesis was accomplished via two approaches, different in length and stereochemical outcome. A longer, indirect approach was realized through otherwise problematic oxidations of the 9,10-dihidrolysergol derivative, to the corresponding aldehyde and carboxylic acid. This was achieved by the use of activated DMSO and a Pinnick oxidation sequence. All four synthesized impurities are used as analytical standards in cabergoline manufacturing processes.
Synthesis and nidation inhibitory activity of a new class of ergoline derivatives
Brambilla,Disalle,Briatico,Mantegani,Temperilli
, p. 421 - 426 (2007/10/02)
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