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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Desethylcarbamoyl cabergoline

Cas:85329-86-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU-CHEM 85329-86-8 Desethylcarbamoyl Cabergoline

Cas:85329-86-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

Desethylcarbamoyl cabergoline

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Cabergoline Impurity D CAS NO.85329-86-8

Cas:85329-86-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Desethylcarbamoyl Cabergoline

Cas:85329-86-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists，engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Desethylcarbamoyl Cabergoline

Cas:85329-86-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

BOC Sciences

BOC Sciences is committed to supplying cost-effective products and services. We provide Cabergoline Impurity D. A metabolite of Cabergoline, having affinity for D1 and D2 dopamine receptors in rat striatum More information please visit: www.bocsci.

Cabergoline Impurity D

Cas:85329-86-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

Desethylcarbamoyl Cabergoline

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Desethylcarbamoyl Cabergoline

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

NUTROCHEM- MANUFACTURE PLACE

best seller Application:API

Desethylcarbamoyl Cabergoline

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Simson Pharma Limited

The system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin

Cabergoline Impurity D

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Finetech Industry Limited

FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the Desethylcarbamoyl Cabergoline, CAS:85329-86-8 with the most competitive price and the

Desethylcarbamoyl Cabergoline

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synova( Tianjin ) Chemical Technology Co,.Ltd

The company have effective management team, professional technical R & D personnel, the service spirit of customer oriented. We have long-term cooperation with famous domestic manufacturer, and excellent customer resources overseas. We are skilled in

Desethylcarbamoyl Cabergoline

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangzhou PI & PI Biotech Inc. Ltd.

Impurities from EP, CP, USP, JP, IP and independent R&D Package:10mg, 25mg, 50mg, 100mg, Other scale please send an equiry Application:For research and development purpose Port:Guangzhou

Cabergoline impurity D

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shenzhen Sumshine Biotech Co., Ltd.

1. Our staff are all biomedical related majors with rich experience in the pharmaceutical industry, and can provide you with more professional services.2. Our supplier has a good quality management system, and the quality of products is reliable and

Cabergoline EP Impurity D

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

NovaChemistry

High purity Application:Pharmaceutical intermediates, Material synthesis and analyzing the expectant ingredients

Cabergoline EP Impurity D

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemie Brunschwig AG

Desethylcarbamoyl Cabergoline

Cas:85329-86-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry
View More

Synthetic route

methyl (6aR,9R,10aR)-7-allyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylate
72821-79-5

methyl (6aR,9R,10aR)-7-allyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylate

1-amino-3-(dimethylamino)propane
109-55-7

1-amino-3-(dimethylamino)propane

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

Conditions
ConditionsYield
In acetic acid Heating;85%
With 2-hydroxypyridin In ethylene glycol at 100℃; for 18h;85%
With acetic acid for 24h; Reflux;74%
9,10-dihydrolysergic acid methyl ester
3006-19-7, 5143-94-2, 35470-53-2, 77842-02-5, 87247-99-2, 96648-31-6, 96648-32-7

9,10-dihydrolysergic acid methyl ester

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dmap / dichloromethane / 16 h / Reflux; Inert atmosphere
2: zinc / methanol; acetic acid / 1.08 h / 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 35 °C
4: acetic acid / 24 h / Reflux
View Scheme
9-methyl 7-(2,2,2-trichloroethyl) (6aR,9R,10aR)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7,9(4H)-dicarboxylate
80993-64-2

9-methyl 7-(2,2,2-trichloroethyl) (6aR,9R,10aR)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7,9(4H)-dicarboxylate

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: zinc / methanol; acetic acid / 1.08 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 35 °C
3: acetic acid / 24 h / Reflux
View Scheme
methyl (6aR,9R,10aR)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylate
30341-92-5

methyl (6aR,9R,10aR)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylate

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 35 °C
2: acetic acid / 24 h / Reflux
View Scheme
Dihydroergocryptine
25447-66-9

Dihydroergocryptine

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium hydroxide; sodium dithionite / water / 4 h / Reflux
2: sulfuric acid / 15 h / 20 °C
3: dmap / dichloromethane / 16 h / Reflux; Inert atmosphere
4: zinc / methanol; acetic acid / 1.08 h / 20 °C
5: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 35 °C
6: acetic acid / 24 h / Reflux
View Scheme
9,10-dihydrolysergic acid
5878-43-3

9,10-dihydrolysergic acid

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sulfuric acid / 15 h / 20 °C
2: dmap / dichloromethane / 16 h / Reflux; Inert atmosphere
3: zinc / methanol; acetic acid / 1.08 h / 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 35 °C
5: acetic acid / 24 h / Reflux
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

tert-butyl (5R,8R,10R)-6-allyl-8-[[[3-(dimethylamino)propyl]amino]carbonyl]ergoline-1-carboxylate
474397-67-6

tert-butyl (5R,8R,10R)-6-allyl-8-[[[3-(dimethylamino)propyl]amino]carbonyl]ergoline-1-carboxylate

Conditions
ConditionsYield
With dmap In tetrahydrofuran at 40℃; for 2h;92%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

C29H46N4OSi

C29H46N4OSi

Conditions
ConditionsYield
Stage #1: (6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide With sodium hydride In tetrahydrofuran at 20℃; for 1.5h;
Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at 20℃; for 1.25h;		86.5%
(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

ethyl isocyanate
109-90-0

ethyl isocyanate

A

cabergoline
81409-90-7

cabergoline

B

(6aR,9R,10aR)-7-allyl-N9-[3-(dimethylamino)propyl]-N4-ethyl-N9-(ethylcarbamoyl)-6a,7,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-4,9(6H)-dicarboxamide
126554-50-5

(6aR,9R,10aR)-7-allyl-N9-[3-(dimethylamino)propyl]-N4-ethyl-N9-(ethylcarbamoyl)-6a,7,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-4,9(6H)-dicarboxamide

Conditions
ConditionsYield
In toluene Heating;A 81%
B 0.57 g
...Expand
(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

methyl isocyanate
624-83-9

methyl isocyanate

N-<3-(dimethylamino)propyl>-N-<(methylamino)-carbonyl>-6-(2-propenyl)-ergoline-8β-carboxamide
126554-48-1

N-<3-(dimethylamino)propyl>-N-<(methylamino)-carbonyl>-6-(2-propenyl)-ergoline-8β-carboxamide

Conditions
ConditionsYield
80%
phenyl isocyanate
103-71-9

phenyl isocyanate

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

N-<3-(dimethylamino)propyl>-N-<(phenylamino)-carbonyl>-6-(2-propenyl)-ergoline-8β-carboxamide
126554-49-2

N-<3-(dimethylamino)propyl>-N-<(phenylamino)-carbonyl>-6-(2-propenyl)-ergoline-8β-carboxamide

Conditions
ConditionsYield
74%
(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

ethyl isocyanate
109-90-0

ethyl isocyanate

cabergoline
81409-90-7

cabergoline

Conditions
ConditionsYield
Stage #1: (6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide With trimethylsilyl trifluoromethanesulfonate; triethylamine In dichloromethane at -2 - 18℃; for 14h;
Stage #2: ethyl isocyanate In dichloromethane at 18℃; for 48h;
Stage #3: With tetrabutyl ammonium fluoride In tetrahydrofuran; dichloromethane at -2℃; for 4h;		68.2%
(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

cabergoline
81409-90-7

cabergoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 40 °C
2: NaHMDS / tetrahydrofuran / -40 - 20 °C
3: propan-2-ol / 18 h / 50 °C
4: aqueous hydrochloric acid / H2O / 1 h / 80 °C
View Scheme
(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

7-allyl-9-ethylcarbamoyl-6a,7,8,9,10,10a-hexahydro-6H-indolo[4,3-fg]quinoline-4-carboxylic acid tert-butyl ester

7-allyl-9-ethylcarbamoyl-6a,7,8,9,10,10a-hexahydro-6H-indolo[4,3-fg]quinoline-4-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 40 °C
2: NaHMDS / tetrahydrofuran / -40 - 20 °C
3: propan-2-ol / 18 h / 50 °C
View Scheme
(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

tert-butyl (5R,8R,10R)-6-allyl-8-[[[3-(dimethylamino)propyl][(ethylamino)carbonyl]amino]carbonyl]ergoline-1-carboxylate
474397-69-8

tert-butyl (5R,8R,10R)-6-allyl-8-[[[3-(dimethylamino)propyl][(ethylamino)carbonyl]amino]carbonyl]ergoline-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 40 °C
2: NaHMDS / tetrahydrofuran / -40 - 20 °C
3: propan-2-ol / 18 h / 50 °C
View Scheme
(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

tert-butyl (5R,8R,10R)-6-allyl-8-[[[3-(dimethylamino)propyl](phenoxycarbonyl)amino]carbonyl]ergoline-1-carboxylate
474397-68-7

tert-butyl (5R,8R,10R)-6-allyl-8-[[[3-(dimethylamino)propyl](phenoxycarbonyl)amino]carbonyl]ergoline-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 40 °C
2: NaHMDS / tetrahydrofuran / -40 - 20 °C
View Scheme
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
85329-86-8

(6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

C26H40N4OSi

C26H40N4OSi

Conditions
ConditionsYield
Stage #1: (6aR,9R,10aR)-7-allyl-N-[3-(dimethylamino)propyl]-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide With sodium hydride In tetrahydrofuran at 20 - 45℃; for 1h;
Stage #2: chloro-trimethyl-silane In tetrahydrofuran at 20℃; for 1h;

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