869-19-2

Basic information

• Product Name: N-Glycyl-L-leucine
• Synonyms: (S)-2-(2-aMinoacetaMido)-4-Methylpentanoic acid;Glycine, leucine -L-;(2S)-2-;(2S)-2-(2-aminoethanoylamino)-4-methyl-pentanoic acid;(2S)-2-(glycylamino)-4-methyl-valeric acid;(2S)-2-[(2-amino-1-oxoethyl)amino]-4-methylpentanoic acid;(2S)-2-[(2-ammonio-1-oxoethyl)amino]-4-methylpentanoate;(2S)-2-[(2-ammonioacetyl)amino]-4-methy
• CAS NO: 869-19-2
• Molecular Formula: C₈H₁₆N₂O₃
• Molecular Weight: 188.22
• EINECS: 212-785-9
• Product Categories: Amino Acids 13C, 2H, 15N;Biochemistry;Oligopeptides;Peptide Synthesis;Amino Acid Derivatives;Amino Acids & Derivatives;amino acid
• Mol File: 869-19-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 233-235 °C(lit.)
• Boiling Point: 323.23°C (rough estimate)
• Flash Point: 202 °C
• Appearance: white solid
• Density: 1.1793 (rough estimate)
• Refractive Index: -35 ° (C=2, H2O)
• Storage Temp.: −20°C
• Solubility: Methanol (Slightly), Water (Sparingly, Sonicated)
• PKA: 3.18(at 25℃)
• CAS DataBase Reference: N-Glycyl-L-leucine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Glycyl-L-leucine(869-19-2)
• EPA Substance Registry System: N-Glycyl-L-leucine(869-19-2)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 869-19-2(Hazardous Substances Data)

Usage

Description

N-Glycyl-L-leucine, also known as glycyl-L-leucine, is a dipeptide composed of glycine and L-leucine joined by a peptide linkage. It is a white solid and is used as a substrate for the assay of glycyl-L-leucine dipeptidase.

Uses

Used in Enzyme Assays:
N-Glycyl-L-leucine is used as a substrate for the assay of glycyl-L-leucine dipeptidase, an enzyme that catalyzes the hydrolysis of this dipeptide into its constituent amino acids, glycine and L-leucine. This application is crucial for studying the activity and function of the enzyme in various biological processes and potential therapeutic applications.

InChI:InChI=1/C8H16N2O3/c1-5(2)3-6(8(12)13)10-7(11)4-9/h5-6H,3-4,9H2,1-2H3,(H,10,11)(H,12,13)/t6-/m0/s1

Upstream product

• 1478-70-2 N-(N-trifluoroacetyl-glycyl)-L-leucine 
• 2666-93-5 (S)-Leu-OMe 
• 15050-24-5 N-(benzyloxycarbonyl)glycyl chloride 
• 1421-69-8 (S)-2-(2-Benzyloxycarbonylamino-acetylamino)-4-methyl-pentanoic acid 
• 6707-71-7 N-(N,N-phthaloyl-glycyl)-L-leucine 
• 144732-62-7 glycyl=>glycyl=>leucine 
• 7352-21-8 Cbz-glycylleucine ethyl ester 
• 61-90-5 L-leucine 

Downstream Products

• 180923-15-3 N-(N-acetyl-glycyl)-leucine 
• 29852-55-9 N-Acetylglycyl-(S)-leucine 
• 92325-89-8 N^α-(2,4-dinitrophenyl)glycyl-L-leucine 
• 688-12-0 N-chloroacetyl-L-leucine 
• 65707-77-9 Diphenylacetyl-glycyl-L-leucin 
• 126530-19-6 acetyltyrozine-glycyl-leucine 
• 126530-20-9 Ac-Tyr-Gly-Leu-Gly-Leu 
• 116653-29-3 Ac-Gly-Phe(NO₂)-Gly-Leu-OH 
• 116653-30-6 Ac-Gly-Gly-Phe(NO₂)-Gly-Leu-OH 
• 687-51-4 H-L-Leu-NH₂ 
• 61-90-5 L-leucine 
• 56-40-6 glycine 
• 598-41-4 H-Gly-NH₂ 
• 14379-80-7 aminoacetic acid hydrazide 

Relevant articles and documents

Disulfide bridged cyclic peptides containing a cgridri sequence useful in control of hypertension

Disulfide bridged cyclic peptides are described which are preferably 13 to 20 amino acid residues in length and which include the endocyclic sequence cys-gly-arg-ile-asp-arg-ile. Peptides of this class are selective for and show picomolar-range affinity for the non-guanyl cyclase-coupled atrial peptide receptor. Affinity for this receptor is associated with potentiation of the mean arterial pressure response to atrial peptide and these peptides are therefore useful in control of hypertension. Peptides of most interest are of the formula wherein X1 is the peptidic fragment ser-ser; wherein X2 is a peptidic fragment selected from gly-ser-gly-leu, gly-ala-gly-leu and gly-leu; wherein X3 is the peptidic fragment asn-ser-phe-arg; wherein m is zero or one, n is one and r is one; and wherein A represents an amino terminus or its pharmaceutically--acceptable salt, and B represents a carboxyl terminus or its pharmaceutically-acceptable ester, amide or salt.

Peptide syntheses with mixed anhydrides from N-acyl-amino acids and saccharin

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