869335-20-6

Basic information

• Product Name: N-Tosyl-4-chloro-3-iodo-7-azaindole
• Synonyms: N-Tosyl-4-chloro-3-iodo-7-azaindole;4-Chloro-3-iodo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine;4-chloro-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 4-chloro-3-iodo-1-[(4-Methylphenyl)sulfonyl]-;3-Iodo-4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine;1-(benzenesulfonyl)-4-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine;1-(Benzenesulfonyl)-4-chloro-3-iodopyrrolo[2,3-b]pyridine;4-chloro-3-iodo-1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridine
• CAS NO: 869335-20-6
• Molecular Formula: C14H10ClIN2O2S
• Molecular Weight: 432.664
• Product Categories: Azaindoles
• Mol File: 869335-20-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 544.829 °C at 760 mmHg
• Flash Point: 283.303 °C
• Appearance: /
• Density: 1.84
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: N-Tosyl-4-chloro-3-iodo-7-azaindole(CAS DataBase Reference)
• NIST Chemistry Reference: N-Tosyl-4-chloro-3-iodo-7-azaindole(869335-20-6)
• EPA Substance Registry System: N-Tosyl-4-chloro-3-iodo-7-azaindole(869335-20-6)

Safety Data

• Hazardous Substances Data: 869335-20-6(Hazardous Substances Data)

Usage

General Description

N-Tosyl-4-chloro-3-iodo-7-azaindole is a chemical compound that is commonly used in organic synthesis and medicinal chemistry. It consists of a tosyl (p-toluenesulfonyl) group attached to a 4-chloro-3-iodo-7-azaindole moiety. This chemical has been studied for its potential biological activities, particularly as a building block for the synthesis of pharmaceutical compounds. Its unique structure and reactivity make it a valuable tool for the development of new drugs and molecular probes. Additionally, this compound may exhibit interesting properties that could be relevant to drug discovery and development. Overall, N-Tosyl-4-chloro-3-iodo-7-azaindole holds promise as a versatile and important intermediate in the synthesis of biologically active molecules.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 869335-73-9 4-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine 
• 55052-28-3 4-chloro-7-azaindole 
• 920965-87-3 4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 918515-16-9 4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 

Downstream Products

• 1613711-94-6 C₁₈H₁₃ClN₂O₂S₂ 
• 1613711-92-4 C₂₁H₁₆ClFN₂O₃S 
• 1613711-88-8 C₂₂H₁₉ClN₂O₃S 
• 1613711-84-4 C₂₁H₁₆Cl₂N₂O₃S 
• 1613711-86-6 C₂₁H₁₇ClN₂O₃S 
• 1613711-80-0 C₂₀H₁₄ClFN₂O₂S 
• 1613710-12-5 3-(3-(pyrrolidin-1-ylsulfonyl)phenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1613710-13-6 3-(4-(pyrrolidin-1-ylsulfonyl)phenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1613710-32-9 2-(4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)phenol 
• 1613710-34-1 3-(3-fluoro-2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1613710-35-2 3-(3,5-difluoro-2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1613710-43-2 3-(2-chloro-3-fluorophenyl)-5-(5-methylfuran-2-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1613709-06-0 3-(2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1613709-07-1 3-(2,4-difluorophenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER

The present application relates to a compound of Formula I, or a salt, hydrate or solvate thereof, as defined herein. The present compounds are found to have pharmacological effects, particularly at MRCK. Further provided are pharmaceutical compositions comprising said compounds. The present invention also relates to the use of these compounds as therapeutic agents, in particular, for the treatment and/or prevention of proliferative diseases, such as cancer.

SUBSTITUTED 1H-PYRROLO [2,3-B] PYRIDINE AND 1H-PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS SALT INDUCIBLE KINASE 2 (SIK2) INHIBITORS

The present invention relates to compounds according to Formulas I, IA or IB: to pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes.

Novel substituted 1H-pyrrolo[2,3-b]pyridines and preparation thereof

The invention relates to novel substituted 1H-pyrrolo[2,3-b]pyridines of the general formula (I) to processes for their preparation and to intermediates therefor.