873-42-7 Usage
Description
2-Amino-3,5-dichloropyrazine is an organic compound with the molecular formula C4H3Cl2N4. It is a heterocyclic compound that features a pyrazine ring with two chlorine atoms at the 3 and 5 positions and an amino group at the 2 position. 2-Amino-3,5-dichloropyrazine is known for its potential applications in the pharmaceutical and chemical industries due to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
2-Amino-3,5-dichloropyrazine is used as a key intermediate in the synthesis of pyrazinones, which are known as inhibitors of protein kinases. These kinases play a crucial role in the progression of various types of cancer, making the compound an important building block for developing anticancer drugs.
Additionally, 2-Amino-3,5-dichloropyrazine is utilized in the synthesis of N-substituted pyrazines through a tandem reaction with o-aminohalopyrazines and isothiocyanates. These N-substituted pyrazines have potential applications in various fields, including as pharmaceutical agents, agrochemicals, and dyes.
Check Digit Verification of cas no
The CAS Registry Mumber 873-42-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,7 and 3 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 873-42:
(5*8)+(4*7)+(3*3)+(2*4)+(1*2)=87
87 % 10 = 7
So 873-42-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H3Cl2N3/c5-2-1-8-4(7)3(6)9-2/h1H,(H2,7,8)
873-42-7Relevant articles and documents
Efficient Halogenation of 2-Aminopyrazine
Grima, Josep,Lizano, Enric,Pujol, M. Dolors
, p. 2000 - 2003 (2019/10/22)
2-Aminopyrazine was halogenated with NIS, NCS, and NBS under different reaction conditions. Chlorination and bromination were achieved with good yields by using acetonitrile as the solvent. However, iodination was only obtained in poor yields. Undoubtedly, the best conditions for both mono-and dihalogenation were the use of NBS, acetonitrile, and microwave assistance for short periods. 3,5-Dibromo-2-Aminopyrazine is an excellent functionalized starting material for the synthesis of nitrogen heterocycles.
