874-31-7

Basic information

• Product Name: 2-Amino-5-chloro-3-methoxypyrazine
• Synonyms: 2-Amino-5-chloro-3-methoxypyrazine;5-Chloro-3-methoxypyrazin-2-ylamine;5-chloro-3-methoxypyrazin-2-amine
• CAS NO: 874-31-7
• Molecular Formula: C₅H₆ClN₃O
• Molecular Weight: 159.575
• Mol File: 874-31-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 128-131 °C
• Boiling Point: 271.113 °C at 760 mmHg
• Flash Point: 117.765 °C
• Appearance: /
• Density: 1.398 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.01±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-5-chloro-3-methoxypyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-chloro-3-methoxypyrazine(874-31-7)
• EPA Substance Registry System: 2-Amino-5-chloro-3-methoxypyrazine(874-31-7)

Safety Data

• Hazardous Substances Data: 874-31-7(Hazardous Substances Data)

Usage

General Description

2-Amino-5-chloro-3-methoxypyrazine is a chemical compound that belongs to the chemical class known as Pyrazines. Pyrazines are compounds containing a pyrazine, which is a six-membered aromatic heterocycle made from two nitrogen atoms and four carbon atoms. The specificity of 2-Amino-5-chloro-3-methoxypyrazine lies in its substitution with the mentioned functional groups (amino, chloro, and methoxy) attached to the pyrazine ring. These functional groups can significantly influence the compound's properties and reactivity. It might be used in a range of industrial, pharmaceutical, or research applications, though information about its specific potential uses may be limited and require specialized knowledge and safety measures during handling.

InChI:InChI=1/C5H6ClN3O/c1-10-5-4(7)8-2-3(6)9-5/h2H,1H3,(H2,7,8)

Upstream product

• 124-41-4 sodium methylate 
• 76537-18-3 3-bromo-5-chloro-2-aminopyrazine 
• 873-42-7 3,5-dichloro-pyrazin-2-ylamine 

Downstream Products

• 173253-74-2 5-dimethylamino-N-(5-chloro-3-methoxy-2-pyrazinyl)-1-naphthalenesulphonamide 

Relevant articles and documents

PYRIDINYL AND PYRAZINYL-(AZA)INDOLSULFONAMIDES

The present invention relates to pyridinyl and pyrazinyl-(aza)indolsulfonamides having GPR17 modulator activity. The compounds have utility in the treatment of a variety of GPR17-associated disorders.

Heterocyclic compounds

The invention concerns pharmaceutically useful compounds of the formula I, in which A1, A2, A3, A4, B1, m, Ar, W, X, Y, Z and R1 have any of the meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful, for example, in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

N-heterocyclic sulfonamides having endothelin receptor activity

The invention concerns pharmaceutically useful compounds of the formula I, in which R 1, R 2, R 3, n, m and Het have any of the meanings defined herein, and their pharmaceutically-acceptable salts, and pharmaceutical compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful, for example, in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processess for the manufacture of the novel compounds and the use of the compounds in medical treatment.