87721-62-8

Basic information

• Product Name: Flestolol
• Synonyms: Flestolol;2-Fluorobenzoic acid 3-[[2-[(aminocarbonyl)amino]-1,1-dimethylethyl]amino]-2-hydroxypropyl ester;ACC-9089;Benzoic acid, 2-fluoro-, 3-((2-((aminocarbonyl)amino)-1,1-dimethylethyl)amino)-2-hydroxypropyl ester;Flestolol [french,spanish];Flestolol [inn];Flestololum;Flestololum [latin]
• CAS NO: 87721-62-8
• Molecular Formula: C₁₅H₂₂FN₃O₄
• Molecular Weight: 327.354
• Mol File: 87721-62-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 491.3°Cat760mmHg
• Flash Point: 250.9°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 1.81E-10mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: Flestolol(CAS DataBase Reference)
• NIST Chemistry Reference: Flestolol(87721-62-8)
• EPA Substance Registry System: Flestolol(87721-62-8)

Safety Data

• Hazardous Substances Data: 87721-62-8(Hazardous Substances Data)

Usage

Uses

Flestolol is?a nonselective, competitive, ultra-short-acting beta-adrenergic?antagonist. It is?metabolized by plasma esterases with an elimination half-life of approximately 6.5 minutes.

InChI:InChI=1/C15H22FN3O4/c1-15(2,9-18-14(17)22)19-7-10(20)8-23-13(21)11-5-3-4-6-12(11)16/h3-6,10,19-20H,7-9H2,1-2H3,(H3,17,18,22)

Upstream product

• 393-52-2 2-Fluorobenzoyl chloride 
• 87484-83-1 1,1-Dimethyl-2-(aminocarbonylamino)ethylamine 
• 85515-51-1 2,3-epoxypropyl o-fluorobenzoate 

Relevant articles and documents

2-hydroxypropylamine heteroaryl ester derivatives

The present invention relates to compounds of the general formula STR1 wherein Ar represents a substituted or unsubstituted heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR2 COR1, --NR2 CONR1 R3, --NR2 SO2 R1, NR2 SO2 NR1 R3, or --NR2 COOR1, wherein R1, R2 and R3 may be alike or different and may be hydrogen, alkyl, alkoxyalkyl cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R1 is not hydrogen when B is --NR2 SO2 R1 or --NR2 COOR1, or R1 and R3 may together with N form a 5 to 7 membered heterocyclic group and the pharmaceutically acceptable salts thereof. The compounds exhibit beta-adrenergic blocking activity and are also useful in the treatment of glaucoma.

propanolamines. 1. Novel β-Blockers with Ultrashort Duration of Action

Novel propanolamines were synthesized and investigated as potential ultrashort-acting β-adrenergic receptor blockers.Many of these analogues exhibited good potency and short duration.The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog.It has been selected as a candidate for further clinical study.Structure-activity relationships and structure-duration relationships for these new β-blockers are also discussed.