88452-86-2

Basic information

• Product Name: 2-Aziridinecarboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, (2S)-
• Synonyms: N-para-toluenesulphonylaziridine-(2S)-carboxylic acid;(S)-N-p-toluenesulfonyl-aziridine-2-carboxylic acid;L-N-tosylaziridine 2-carboxylic acid
• CAS NO: 88452-86-2
• Molecular Formula: C10H11NO4S
• Molecular Weight: 241.268
• Mol File: 88452-86-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Aziridinecarboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aziridinecarboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, (2S)-(88452-86-2)
• EPA Substance Registry System: 2-Aziridinecarboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, (2S)-(88452-86-2)

Safety Data

• Hazardous Substances Data: 88452-86-2(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 105424-75-7 methyl (2S)-1-[(4-methylphenyl)sulfonyl]aziridine-2-carboxylate 

Downstream Products

• 127700-58-7 (2S)-N-para-toluenesulphonylaminoheptanoic acid tert-butyl ester 
• 127700-64-5 (2S)-(N-para-toluenesulphonylamino)hexanoic acid tert-butyl ester 
• 127700-68-9 (2R)-(N-para-toluenesulphonylamino)-2-methylpropanoic acid tert-butyl ester 
• 151074-48-5 (2S)-2-(1'-butan-pentan-1'-ol)N-para-toluenesulphonylaziridine 
• 64143-84-6 (2S)-(N-para-toluenesulphonylamino)-4-methylpentanoic acid tert-butyl ester 
• 63-91-2 L-phenylalanine 
• 910040-99-2 methyl (2S)-6-(N,N-dibenzylamine)-2-(para-toluenesulfonylamino)-hex-4-ynoate 
• 13505-32-3 N-tosyl-(S)-phenylalanine 
• 109075-04-9 2(S)-butyric acid 
• 910040-98-1 (2S)-6-(N,N-dibenzylamino)-2-(para-toluenesulfonylamino)-hex-4-ynoic acid 
• 67850-42-4 3-(1H-indol-3-yl)-2(S)-{[(4-methylphenyl)sulfonyl]amino}propanoic acid 
• 159141-13-6 (2S)-N-para-toluenesulfonylpropynylglycine 
• 110579-31-2 (2S)-N-para-toluenesulfonylvinylglycine 

Relevant articles and documents

Synthesis of the suicide substrate D-propargylglycine stereospecifically labelled with deuterium and investigation of its oxidation by D-amino acid oxidase

Stereospecifically deuteriated samples of D-propargylglycine 1 have been prepared by reaction of the labelled Pmc-protected aziridine free acids 22 with a lithium acetylide followed by deprotection. These samples have been used to show that D-amino acid oxidase, in converting D-propargylglycine to the lactone 5, deprotonates C-3 in a non-stereospecific manner. This strongly supports the idea that non-enzymic deprotonation is a key step in the formation of this compound.

Amino Acid Synthesis via Ring Opening of N-Sulphonyl Aziridine-2-Carboxylate Esters with Organometallic Reagents.

Nucleophilic ring opening of optically active N-sulphonyl aziridine-2-carboxylate esters with organometallic reagents has been investigated as a method of preparation of optically active amino acids.Key Words: aziridine-2-carboxylate, cuprate, nucleophilic ring opening, amino acid