910299-74-0 Usage
Description
11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione is a chemical compound belonging to the steroid family, specifically a derivative of androstane. It is characterized by the presence of two hydroxyl groups at the 11β and 16α positions, and a ketone group at the 3 and 17 positions. 11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione has a unique molecular structure that contributes to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione is used as an impurity in budesonide tablets for the treatment of various inflammatory conditions. Budesonide is a corticosteroid that exhibits potent anti-inflammatory and immunosuppressive properties, making it effective in managing conditions such as asthma, allergic rhinitis, and inflammatory bowel diseases. The presence of 11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione as an impurity in budesonide tablets indicates its potential role in the synthesis or formulation process of the drug, although its specific contribution to the therapeutic effects of budesonide remains to be elucidated.
Check Digit Verification of cas no
The CAS Registry Mumber 910299-74-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,0,2,9 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 910299-74:
(8*9)+(7*1)+(6*0)+(5*2)+(4*9)+(3*9)+(2*7)+(1*4)=170
170 % 10 = 0
So 910299-74-0 is a valid CAS Registry Number.
910299-74-0Relevant articles and documents
Photochemistry of desonide, a non-fluorinated steroidal anti-inflammatory drug
Iqbal, Jawaid,Husain, Adil,Gupta, Anamika
, p. 836 - 838 (2006)
The photochemistry of anti-inflammatory drug desonide (De, 1) was studied in aerobic as well as in anaerobic condition with different irradiation wavelengths (254, 310 nm) in acetonitrile and 2-propanol. All photoproducts obtained were isolated and characterized on the basis of IR, 1H-, 13C-NMR spectroscopy and elemental analysis study. The products were: 11β,21-dihydroxy-16α,17α-(1-methylethylidenedioxy)-1,5- cyclopregn-3-ene-2,20-dione 2 (254 nm), 11β-hydroxy-16α,17α-(1- methylethylidenedioxy)androsta-1,4-diene-3-one 3 (310 nm/2-propanol), 17β-hydroperoxy-11β-hydroxy-16α,17α-(1- methylethylidenedioxy)androsta-1,4-diene-3-one 4 (310 nm/O2/2- propanol). Cyclohexadienone moiety in ring A and keto group at C17 were found to be deeply modified by UV light therefore, loss of biological activity both during storage and in vivo can not be ruled out.
